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https://pubs.rsc.org/en/content/articlelanding/2012/nj/c1nj20408d#!
This in itself however depends largely on the availability of safe and efficient siRNA delivery systems. In this context, dendrimers have attracted considerable attention as siRNA vectors due to their well-defined structures and multivalent features. The present review offers a …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816686/
Carbosilane dendrimers were as effective as viral vectors in terms of their siRNA delivery and transfection efficiency. Carbosilane dendrimers with sixteen positive charges/molecule caused strong repression of various interleukins in macrophages involved in autoimmune diseases suggesting a potential pharmacological application of this dendrimer [ 106 ].Author: Swati Biswas, Vladimir P. Torchilin
https://www.researchgate.net/publication/255755059_Dendrimers_as_Non-Viral_Vectors_for_siRNA_Delivery
In this context, dendrimers have attracted considerable attention as siRNA vectors due to their well-defined structures and multivalent features. The present review offers a brief overview of the current status of dendrimers as siRNA delivery vectors, focusing on the different dendrimers...
https://www.academia.edu/13276112/Dendrimers_as_non-viral_vectors_for_siRNA_delivery
The active RISC complex (Fig. 2). can then be recycled for the destruction of identical mRNA targets. One special family of polymeric vectors that are emerging as promising non-viral vectors for siRNA delivery are cationic created a completely new era of RNA therapeutics…
https://www.hindawi.com/journals/tswj/2013/630654/
Considering the safety issues and other drawbacks of viral approach, the nonviral vectors for siRNA delivery are increasingly concerned as the alternatives of viral ones. Among versatile non-viral vectors, dendrimer-based siRNA carriers have been gradually explored since their performance in DNA delivery was approved.Author: Jiangyu Wu, Weizhe Huang, Ziying He
https://onlinelibrary.wiley.com/doi/full/10.1111/jphp.12104
Jul 19, 2013 · Dendrimers for non‐viral gene delivery Various viral and non‐viral gene delivery systems have been developed for the delivery of genetic materials to different organs, tissues and cells. While viral vectors are the most capable vehicles, their limitations include their high carcinogenicity and immunogenicity in vivo.Author: Sahil P. Chaplot, Ilva D. Rupenthal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914146/
Aug 02, 2010 · While F2-1, the most effective DNA delivery vector of the triazine dendrimers investigated 28, 29 was not able to mediate RNAi, the rigid triazine dendrimers G2-1g and G2-5 which were only moderately effective gene delivery vectors 29 were the most promising for in vitro siRNA delivery. In this study, the interplay of a number of characteristics such as stability, size, surface …Author: Olivia M. Merkel, Meredith A. Mintzer, Damiano Librizzi, Olga Samsonova, Tanja Dicke, Brian Sproat, ...
https://www.europepmc.org/articles/PMC2773017/
Sep 01, 2009 · Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity. Find the latest peer-reviewed research articles and preprints on Coronavirus here. Feedback Complete survey. Sign in or create an account. https ...Author: Olivia M. Merkel, Meredith A. Mintzer, Johannes Sitterberg, Udo Bakowsky, Eric E. Simanek, Thomas Ki...
https://www.sciencedirect.com/science/article/pii/S0378517319301966
May 01, 2019 · Carbosilane dendrimers with phosphonium terminal groups are low toxic non-viral transfection vectors for siRNA cell deliveryAuthor: Regina Herma, Dominika Wrobel, Michaela Liegertová, Monika Müllerová, Tomáš Strašák, Marek Maly, Ale...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347098/
Jan 01, 2015 · The optimal vector and delivery system depends on the target cells and its characteristics, duration of expression and the size of the genetic material to be incorporated in the vector [3,4].The present vectors used for gene therapy are broadly classified as Viral vectors, Non-viral vectors and engineered vectors. The non-viral vectors are ...Author: Murali Ramamoorth, Aparna Narvekar
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