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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Cell type-specific delivery can also be achieved by linking siRNA to an RNA aptamer or aptamer–siRNA chimeras. Aptamers are oligonucleic acids or peptides that bind to a specific target molecule. These chimeras have the theoretical advantage that their relatively small molecular weights may improve the transport in tissue interstitium.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272875/
Sep 20, 2016 · In recent years, pulmonary delivery of RNAi molecules is being explored as a new treatment for lung cancer . Genes that are associated with tumor cell growth and drug resistance are potential targets. Table 2 summarizes some recent in vivo studies of pulmonary RNAi delivery for lung cancer treatment.Author: Yingshan Qiu, Jenny K. W. Lam, Susan W. S. Leung, Wanling Liang
https://www.alliedacademies.org/articles/rethinking-delivery-viral-vectors-and-rna-interference-7646.html
Efficient delivery of nucleic acids to their intended target cells remains the major complication holding back the widespread adoption of RNA interference (RNAi) therapies. In recent years, substantial progress has been made in the development of delivery systems for small interfering RNAs ( siRNA s), including lipid formulations, nanoparticles and functional groups covalently coupled to siRNA s.Author: Jens Kurreck
http://veritasbiollc.com/rna-delivery-technology/
Delivery of RNAi: A novel approach for delivery of Nucleic Acids to Cells Provides a solution to the rate-limiting step in the delivery of RNA-based drugs
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