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https://www.sciencedirect.com/science/article/pii/S1818087614000646
In recent years, siRNA drug development has experienced highs and lows. The attitude of big pharmaceutical companies to RNAi drugs has also become over-optimistic. In summary, a good delivery system is the key to siRNA drug development.Author: Cong-fei Xu, Jun Wang
https://www.fda.gov/drugs/news-events-human-drugs/new-class-drugs-fulfills-promise-rna-based-medicine
RNAi was first discovered by Craig Cameron Mello and Andrew Fire, who won the 2006 Nobel prize for Physiology and Medicine for their groundbreaking work. ... These drugs also require a delivery ...
https://health.ucsd.edu/news/releases/Pages/2014-11-17-rnai-drug-delivery.aspx
Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great therapeutic potential to treat a number of diseases, especially cancer and pandemic viruses. The problem is delivery — it is extremely difficult to get RNAi drugs inside the cells in which they are needed. To overcome this hurdle, researchers at University of California, San Diego School of Medicine ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418169/
Several RNAi-based drugs are in various stages of clinical investigation. This review summarizes the ongoing research endeavors on RNAi in molecular medicine, delivery systems for RNAi-based drugs, and a compendium of RNAi drugs in different stages of clinical development.Author: Jing Chen, Jianping Xie
https://www.genengnews.com/magazine/106/improving-delivery-of-rnai-drugs/
RNAi has quickly advanced from its initial discovery in worms to a key genetic research tool, and one of the most promising therapeutics to change the future of medicine.
https://www.nature.com/articles/s41573-019-0017-4
Mar 07, 2019 · In this Review, we discuss key advances in the design and development of RNAi drugs leading up to this landmark achievement, the state of the current clinical pipeline and prospects for future ...Author: Ryan L. Setten, Ryan L. Setten, John J. Rossi, John J. Rossi, Si-ping Han, Si-ping Han
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