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https://www.ncbi.nlm.nih.gov/pubmed/21935894
If the targeting moiety is designed to contain the cargo of an RNAi mediator without impacting its paratope, directed delivery can be achieved. In this article, we review the state of art in delivery technology for RNA mediators and address how this technique could soon be used to enhance the efficacy of the numerous small RNA therapeutic programs currently under evaluation.Author: Lance P. Ford, Masoud M. Toloue
https://onlinelibrary.wiley.com/doi/abs/10.1002/wrna.12
Wiley Interdisciplinary Reviews: RNA ... Delivery of RNAi mediators. Lance P. Ford. Corresponding Author. E-mail address: [email protected]. Bioo Scientific, 3913 Todd Lane Suite 312, Austin, TX 78744, USA. Bioo Scientific, 3913 Todd Lane Suite 312, …Author: Lance P. Ford, Masoud M. Toloue
https://www.researchgate.net/publication/51659700_Delivery_of_RNAi_mediators
Delivery of RNAi mediators. September 2010; WIREs RNA 1(2 ... we review the state of art in delivery technology for RNA mediators and address how this technique could soon be used to enhance the ...
https://www.deepdyve.com/lp/wiley/delivery-of-rnai-mediators-g78kz76XOs
Sep 01, 2010 · Delivery of RNAi mediators Given the matured understanding of antibody‐mediated delivery techniques, it is possible to rationally design delivery vehicles that circulate in the blood stream and are specifically delivered into target organs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272875/
Sep 20, 2016 · RNA interference (RNAi) is a potent and specific post-transcriptional gene silencing process. Since its discovery, tremendous efforts have been made to translate RNAi technology into therapeutic applications for the treatment of different human diseases including respiratory diseases, by manipulating the expression of disease-associated gene(s).Author: Yingshan Qiu, Jenny K. W. Lam, Susan W. S. Leung, Wanling Liang
https://www.mdpi.com/1420-3049/21/9/1249/htm
RNA interference (RNAi) is a potent and specific post-transcriptional gene silencing process. Since its discovery, tremendous efforts have been made to translate RNAi technology into therapeutic applications for the treatment of different human diseases including respiratory diseases, by manipulating the expression of disease-associated gene(s).Author: Yingshan Qiu, Jenny K. W. Lam, Susan W. S. Leung, Wanling Liang
https://www.alliedacademies.org/articles/rethinking-delivery-viral-vectors-and-rna-interference-7646.html
The time has come to re-consider viral vectors in order to overcome the complications and allow efficient, specific and well-tolerated delivery in RNAi applications. Following the discovery that RNAi can be employed in mammalian cells for the specific silencing of a gene-of-interest (Elbashir et al, 2001; Kurreck, 2009) the field experienced an ...Author: Jens Kurreck
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559924/
Jun 25, 2006 · Here, we discuss progress that has been made to improve targeted delivery of siRNA in vivo for each of these strategies. INTRODUCTION. The functional mediators of RNA interference (RNAi) are small interfering RNAs (siRNA) [1, 2]. These double-stranded RNA molecules are typically 19 to 23 nucleotides in length, and consequently have a molecular ...Author: Sabrina Oliveira, Gert Storm, Raymond M. Schiffelers
https://www.sciencedirect.com/science/article/pii/S1525001616319864
Introduction. The key to enabling therapeutics based on RNA interference (RNAi) is the safe and efficacious delivery of short interfering RNAs (siRNAs), the mediators of RNAi, to the appropriate tissues, cells, and ultimately, intracellular compartments where the natural RNAi machinery may be engaged for target mRNA silencing resulting in protein knockdown.Author: Martin A Maier, Muthusamy Jayaraman, Shigeo Matsuda, Ju Liu, Scott Barros, William Querbes, Ying K T...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112363/
Nov 17, 2016 · Delivery of dsRNA using chemically modified molecules, polymer nanoparticles, liposomes, viruses or bacteria, could increase efficacy in attaining a potent RNAi response. The choice of the delivery method and the choice of formulation would of course depend on the circumstances, on the target insect and on the reason for impaired RNAi-efficiency.Author: Mallikarjuna R. Joga, Moises J. Zotti, Guy Smagghe, Olivier Christiaens
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