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https://www.ncbi.nlm.nih.gov/pubmed/12387671
Drug delivery across the skin. ... These new and exciting methods for drug delivery are already increasing the number and quality of dermal and transdermal therapies. This review discusses the different types of permeation enhancement, both classic and innovative, and summarises the current strengths and shortcomings in the field with an ...Author: Elka Touitou
https://www.tandfonline.com/doi/abs/10.1517/14712598.2.7.723
Jul 09, 2014 · Drug delivery across the skin Elka Touitou Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, PO Box 12065, Jerusalem, 91120, Israel Pages 723-733Author: Elka Touitou
https://www.researchgate.net/publication/7753673_Drug_delivery_across_the_skin
Lipid-based drug carriers (liposomes, niosomes, nanoparticle microemulsions, etc.) were proposed as alternative, low-risk delivery vehicles. Such suspensions provide an improved drug reservoir on...
https://www.tandfonline.com/doi/abs/10.1517/13543784.6.12.1887
Jul 09, 2014 · Drug bioavailability for TTS delivery is typically below 50%, avoiding the first pass effect. Wider, hydrophilic channels can be generated by skin poration, with the aid of a small electrical current (> 0.4 mA/cm2) across the skin (iontophoresis) or therapeutic ultrasound (few W/cm2; sonoporation).Author: Gregor Cevc
https://www.researchgate.net/publication/11073613_Drug_delivery_across_the_skin
A major problem associated with the drug delivery across the skin, is the barrier nature of the skin, which is primarily located in the outer layer of the skin i.e. the stratum cor- neum.
http://europepmc.org/abstract/MED/15989590
Drug bioavailability for TTS delivery is typically below 50%, avoiding the first pass effect. Wider, hydrophilic channels can be generated by skin poration, with the aid of a small electrical current (> 0.4 mA/cm2) across the skin (iontophoresis) or therapeutic ultrasound (few W/cm2; sonoporation).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
This abrasive mechanism, which is related to sand blasting on the microscopic scale, has been shown to increase skin permeability to drugs, including lidocaine and 5-fluorouracil, which suggests possible applications in transdermal drug delivery 58. Vaccine delivery across the skin has also been facilitated by skin abrasion using sandpaper 59.Author: Mark R Prausnitz, Robert Langer
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