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https://www.nature.com/articles/d41586-019-03071-9
Oct 16, 2019 · Delivery difficulties brought the nascent research field to its knees, but approval of the first RNA interference drug offers hope. Delivery difficulties brought the nascent research field to its ...Author: Bianca Nogrady
https://www.ncbi.nlm.nih.gov/pubmed/26738473
A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although there were initial difficulties in achieving efficacious results with RNAi without toxic side effects, advances in delivery and improved chemistry made this resurgence possible.Author: Maggie L. Bobbin, John J. Rossi
https://www.transcodetherapeutics.com/
TransCode Therapeutics, Inc., an RNAi Oncology Company, is focused on the discovery, development and commercialization of a pipeline of innovative diagnostics and therapeutics for the detection and treatment of cancer, with an initial focus on metastasis.
https://www.ddw-online.com/therapeutics/p322575-current-trends-in-rna-therapeutics-development.html
New in vivo RNA delivery technologies including LNP or PNP systems and the use of aptamer or antibody conjugation have overcome some of the challenges associated with delivery of RNA-based therapeutics, with the selection of the delivery system depending on the therapeutics properties, type of target cell and desired delivery route.
https://www.alliedacademies.org/articles/rethinking-delivery-viral-vectors-and-rna-interference-7646.html
Efficient delivery of nucleic acids to their intended target cells remains the major complication holding back the widespread adoption of RNA interference (RNAi) therapies. In recent years, substantial progress has been made in the development of delivery systems for small interfering RNAs ( siRNA s), including lipid formulations, nanoparticles ...Author: Jens Kurreck
http://rnai.technology/rnai-type/top-rani-gene-therapy-companies/
Top RNAi and gene therapy companies, ddRNAi, DNA vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743652/
RNA interference. RNA interference (RNAi) was first demonstrated in a nematode (Caenorhabditis elegans), where delivery of exogenous long, double-stranded RNA (dsRNA) effectively silenced the expression of a gene (encoding for a myofilament protein) by inducing degradation of a homologous host mRNA.The mechanism that mediated gene silencing involved degradation of dsRNA into short …Author: Ryszard Kole, Adrian R. Krainer, Sidney Altman
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression of disease-relevant genes. RNA-based drugs, including short interfering RNAs and antisense oligonucleotides, are particularly promising ...Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://www.amazon.com/Interference-Therapeutics-Advances-Delivery-Technology-ebook/dp/B00AKIG86M
The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference.5/5(1)
https://www.nature.com/articles/s41573-019-0017-4
Mar 07, 2019 · The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all human cells. Small double-stranded RNA molecules can …Author: Ryan L. Setten, Ryan L. Setten, John J. Rossi, John J. Rossi, Si-ping Han, Si-ping Han
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