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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046792/
May 27, 2014 · The RNA interference (RNAi) technique based on small interfering RNA (siRNA) or microRNA (miRNA) has shown great potential for cancer therapy given its unique sequence-specific gene silencing effect. 1−3 However, clinical translation of RNAi has stalled over a decade due to the difficulties in delivering RNAs into the tumor tissues and, more importantly, into the tumor cells in vivo.Author: Ki Young Choi, Oscar F. Silvestre, Xinglu Huang, Kyung Hyun Min, Gregory P. Howard, Naoki Hida, Albe...
https://www.tandfonline.com/doi/pdf/10.4161/cc.5.18.3192
Unfortunately, delivery of these RNA duplexes has been challenging, halting rapid development of RNAi-based therapies. In this review we present current advancements in the field of siRNA delivery methods, including the pros and cons of each method. INTRODUCTION RNA Interference (RNAi) is a natural mechanism of gene silencing conserved in plant
https://media.nature.com/original/magazine-assets/d41586-019-03071-9/d41586-019-03071-9.pdf
essary for the interference action 1,2, and single-stranded RNA can also be chemically stabilized to survive inside the body. Lipid nanoparticles and engineered RNA molecules aren’t the only options being explored in the quest to overcome RNAi’s delivery chal - lenges. Anil Sood, co-director of the Center for RNA Interference and Non-Coding ...
https://www.jove.com/video/57390/double-stranded-rna-oral-delivery-methods-to-induce-rna-interference
Double-stranded RNA Oral Delivery Methods to Induce RNA Interference in Phloem and Plant-sap-feeding Hemipteran Insects Saikat Kumar B. Ghosh 1 , Wayne B. Hunter 2 , Alexis L. Park 1 , Dawn E. Gundersen-Rindal 1Author: Saikat Kumar B. Ghosh, Wayne B. Hunter, Alexis L. Park, Dawn E. Gundersen-Rindal
https://www.nature.com/articles/d41586-019-03071-9
Oct 16, 2019 · Delivery difficulties brought the nascent research field to its knees, but approval of the first RNA interference drug offers hope. Bianca Nogrady Bianca Nogrady is a freelance science writer in ...Author: Bianca Nogrady
https://www.nature.com/articles/nplants2016207
Jan 09, 2017 · Topical application of pathogen-specific double-stranded RNA (dsRNA) for virus resistance in plants represents an attractive alternative to …Author: Neena Mitter, Elizabeth A. Worrall, Karl E. Robinson, Peng Li, Ritesh G. Jain, Christelle Taochy, St...
https://www.alliedacademies.org/articles/rethinking-delivery-viral-vectors-and-rna-interference-7646.html
Efficient delivery of nucleic acids to their intended target cells remains the major complication holding back the widespread adoption of RNA interference (RNAi) therapies. In recent years, substantial progress has been made in the development of delivery systems for small interfering RNAs ( siRNA s), including lipid formulations, nanoparticles ...Author: Jens Kurreck
http://rnai.technology/rnai-type/top-rani-gene-therapy-companies/
Top RNAi and gene therapy companies, ddRNAi, DNA vaccines
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