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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference (RNAi) is caused by small (21 − 23 bases long) single-stranded RNA molecules (small-interfering RNA; siRNA), which trigger silencing of target genes in a sequence-specific manner [1,2]. The siRNA's sequence is ‘anti-sense’ (or complementary) to a specific stretch of the messenger RNA (mRNA) transcribed by the target gene.Author: Saroj P Mathupala
https://www.nature.com/articles/nature05901
Jun 17, 2007 · Attachment of a piece of viral protein to a small RNA achieves transfer of the RNA into neuronal cells in cell culture. This was also able to deliver an antiviral siRNA specifically into the ...Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.sciencedirect.com/topics/neuroscience/small-interfering-rna
Small interfering RNA (siRNA) mediated inhibition of gene expression has rapidly become a major tool for in vitro analysis of protein function. In vivo gene silencing by siRNAs will play an important role for target validation and is the first step towards the development of siRNA-based therapeutics.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198620/
The pioneer work on RNA interference (RNAi) by Fire, Mello, and their colleagues was soon followed by the proof-of-principle experiments conducted by Tuschl group to establish the successful application of synthetic small-interfering RNA (siRNA) in sequence-specific suppression of endogenous and heterologous genes in mammalian cell lines ...Author: Kaushik Singha, Ran Namgung, Won Jong Kim
https://advances.sciencemag.org/content/5/9/eaaw6499.full
Sep 01, 2019 · RNA interference (RNAi) technology can specifically silence the expression of a target gene and has emerged as a promising therapeutic method to treat cancer. In the present study, we showed that natural halloysite nanotube (HNT)–assisted delivery of an active small interfering RNA (siRNA) targeting receptor-interacting protein kinase 4 ( RIPK4 ) efficiently silenced its expression to …Author: Jianye Liu, Yi Zhang, Qinghai Zeng, Hongliang Zeng, Xiaoming Liu, Pei Wu, Hongyi Xie, Leye He, Zhi L...
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/small-interfering-rna
Small interfering RNA (siRNA), with length in 20–25 bp, is a short double-stranded RNA molecule. siRNA has been recognized as a promising therapeutic for antiviral, anticancer, or other genetic diseases (Li & Huang, 2006; Xue, Liu, & Wong, 2014; Zhao, Mi, & Feng, 2013). Currently, biomedical application of siRNA is still limited due to the ...
https://www.liebertpub.com/doi/10.1089/hum.2008.928
The ability of synthetic small interfering RNA (siRNA) to potently, but reversibly, silence genes in vivo, has made them particularly well suited as a drug therapeutic. Development of therapeutics using siRNA has advanced rapidly, with five different clinical trials ongoing and several more poised to enter the clinic in the coming years.Author: Antonin R. de Fougerolles
http://www.thno.org/v04p1211.htm
Functional Nanostructures for Effective Delivery of Small Interfering RNA Therapeutics . Cheol Am Hong 1, Yoon Sung Nam 1,2,3 . 1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701, Republic of Korea; 2.
http://www.nature.com/articles/nbt1101
May 22, 2005 · Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic application. We designed a protamine-antibody fusion protein to deliver siRNA to HIV-infected or ...Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
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