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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference (RNAi) is caused by small (21 − 23 bases long) single-stranded RNA molecules (small-interfering RNA; siRNA), which trigger silencing of target genes in a sequence-specific manner [1,2]. The siRNA's sequence is ‘anti-sense’ (or complementary) to a specific stretch of the messenger RNA (mRNA) transcribed by the target gene.Author: Saroj P Mathupala
https://www.ncbi.nlm.nih.gov/pubmed/19441914
OBJECTIVE: Most pre-clinical and clinical studies on delivery of RNAi to the CNS have utilized invasive, intra-cerebral delivery of RNA to the targeted tissue. Thus, methods need to be developed to facilitate delivery of therapeutically significant quantities of RNA to the CNS via the systemic route, and to elicit clinically significant RNAi effects within the CNS tissues.Author: Saroj P Mathupala
https://www.nature.com/articles/nature05901
Jun 17, 2007 · Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA…Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.researchgate.net/publication/24427016_Delivery_of_small-interfering_RNA_siRNA_to_the_brain
Delivery of small-interfering RNA (siRNA) to the brain Article · Literature Review (PDF Available) in Expert Opinion on Therapeutic Patents 19(2):137-40 · March 2009 with 54 Reads
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572210/
Mar 30, 2007 · In DNA-based RNAi, a plasmid DNA encodes for a short hairpin RNA (shRNA). In RNA-based RNAi, a siRNA duplex is chemically synthesized without a DNA intermediate. Drug delivery is the rate-limiting step in the translation of RNAi based therapeutics from cell culture to in vivo therapeutics in animals and humans.Author: William M. Pardridge
https://www.sciencedirect.com/science/article/pii/S0142961213009848
To improve the efficiency of small interfering RNA (siRNA) delivery to the brain, we developed a nose-to-brain delivery system combined with cell-penetrating peptide (CPP) modified nano-micelles comprising polyethylene glycol–polycaprolactone (PEG–PCL) copolymers conjugated with the CPP, Tat (MPEG–PCL–Tat).Author: T. Kanazawa, F. Akiyama, S. Kakizaki, Y. Takashima, Y. Seta
https://www.ncbi.nlm.nih.gov/pubmed/17434235
Mar 30, 2007 · shRNA and siRNA delivery to the brain. Pardridge WM(1). Author information: (1)Department of Medicine, UCLA Warren Hall 13-164, 900 Veteran Ave., Los Angeles, CA 90024, USA. [email protected] The limiting factor in in vivo RNA interference (RNAi) is delivery.Author: William M. Pardridge
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be developed. Here we show that exosomes—endogenous nano-vesicles …Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.researchgate.net/publication/6263796_Transvascular_delivery_of_small_interfering_RNA_to_the_central_nervous_system
A major impediment in the treatment of neurological diseases is the presence of the blood-brain barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA…
https://www.ncbi.nlm.nih.gov/pubmed/21423189
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Alvarez-Erviti L(1), Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Author information: (1)Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
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