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https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pubmed/21423189
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Alvarez-Erviti L(1), Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Author information: (1)Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://altogen.com/InVivoTransfection3.pdf
siRNA was used for the empirical optimization of the electropora-tion protocol. The amount of encapsulated siRNA was assayed after ultracentrifugation and lysis of exosomes (Supplementary Fig. 3a,b). Electroporation at 400 V and 125 µF resulted in the greatest retention Delivery of sirNA to the mouse brain by systemic injection of targeted ...
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Finally, we outline how to use exosomes to efficiently deliver siRNA in vitro and in vivo in mouse brain. Examples of anticipated results in which exosome-mediated siRNA delivery is …Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204174/
Aug 11, 2014 · We have used α-Syn small interfering RNA (siRNA) to reduce total and aggregated α-Syn levels in mouse brains. To achieve widespread delivery of siRNAs to the brain we have peripherally injected modified exosomes expressing Ravies virus glycoprotein loaded with siRNA. Normal mice were analyzed 3 or 7 days after injection.Author: JM Cooper, PB Wiklander, JZ Nordin, R Al-Shawi, MJ Wood, M Vithlani, AH Schapira, JP Simons, S El-An...
https://www.sciencedirect.com/science/article/pii/S0168365918302190
Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease. ... , and delivery of BACE1 siRNA to the mouse brain by systemic injection. Nevertheless, for the BACE1 inhibition, only overcoming the BBB is insufficient.Author: Pengzhen Wang, Xiaoyao Zheng, Qian Guo, Peng Yang, Xiaoying Pang, Kang Qian, Wei Lu, Qizhi Zhang, Xi...
https://www.academia.edu/15139145/Delivery_of_siRNA_to_the_mouse_brain_by_systemic_injection_of_targeted_exosomes
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
https://reference.medscape.com/medline/abstract/21423189
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. ... efficient, tissue-specific and nonimmunogenic delivery technologies must be developed. Here we show that exosomes-endogenous nano-vesicles that transport RNAs and proteins-can deliver short interfering (si)RNA to the brain in mice. To reduce ...
https://www.researchgate.net/publication/50596721_Alvarez-Erviti_L_Seow_Y_Yin_H_Betts_C_Lakhal_S_and_Wood_MJA_Delivery_of_siRNA_to_the_mouse_brain_by_systemic_injection_of_targeted_exosomes_Nat_Biotechnol_29_341-345
Alvarez-Erviti, L, Seow, Y, Yin, H, Betts, C, Lakhal, S and Wood, MJA. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.
https://www.paediatrics.ox.ac.uk/publications/127173
To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be developed. Here we show that exosomes-endogenous nano-vesicles that transport RNAs and proteins-can deliver short interfering (si)RNA to the brain in mice. To reduce immunogenicity, we used self-derived dendritic cells for exosome production.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
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