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https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be engineered to transport siRNA specifically to the brain in mice.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pubmed/21423189
The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in …Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572210/
Mar 30, 2007 · The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Figs. 6 and and7 7 demonstrate the delivery of PNA antisense agents to brain in vivo [ 43 ]. siRNA duplexes can be monobiotinylated [ 52 ], which allows for high efficiency attachment to molecular Trojan horses using avidin-biotin technology.Author: William M. Pardridge
https://www.paediatrics.ox.ac.uk/publications/127173
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Alvarez-Erviti L., Seow Y., Yin H., Betts C., Lakhal S., Wood MJA. To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be developed.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://altogen.com/InVivoTransfection3.pdf
siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in Alzheimer’s disease, in wild-type mice. Despite recent advances in delivering siRNA, targeting specific tissues or cell types while avoiding nonspecific delivery, especially to the liver, remains challenging.
https://www.academia.edu/15139145/Delivery_of_siRNA_to_the_mouse_brain_by_systemic_injection_of_targeted_exosomes
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
https://www.ncbi.nlm.nih.gov/pubmed/?term=Delivery+of+siRNA+to+the+mouse+brain+by+systemic+injection+of+targeted+exosomes
1: Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · By using this method, we demonstrated specific delivery of siRNA to neurons in the brain following systemic delivery in mice, with up to 60% RNA and protein knockdown predominantly in the midbrain, cortex and striatum, and little homing of exosome cargo to the liver.Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://advances.sciencemag.org/content/6/15/eaaz6980.full
3 days ago · Through systemic delivery of Exo-srIκB in a septic mouse model, we demonstrated that exosomes are delivered primarily to neutrophils and macrophages, which are key players in the overwhelming inflammatory response of sepsis. ... Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29, ...
https://www.sciencedirect.com/science/article/pii/S1525001620300538
Apr 08, 2020 · We previously demonstrated efficient delivery of siRNA to the tumor nodules that develop in the plasmid-injected mice. 46 As UBR5 and UBR2 have been reported to be overexpressed in some types of cancer, 17, 18 we assessed the level of mRNA expression of all four UBR-ubiquitin ligases and found that none was upregulated in our specific HCC model .Author: Dominique Leboeuf, Tatiana Abakumova, Tatiana Prikazchikova, Luke Rhym, Daniel G. Anderson, Timofei ...
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