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https://www.ncbi.nlm.nih.gov/pubmed/21423189
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Alvarez-Erviti L(1), Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Author information: (1)Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by …Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.researchgate.net/profile/Haifang_Yin/publication/50596721_Alvarez-Erviti_L_Seow_Y_Yin_H_Betts_C_Lakhal_S_and_Wood_MJA_Delivery_of_siRNA_to_the_mouse_brain_by_systemic_injection_of_targeted_exosomes_Nat_Biotechnol_29_341-345/links/0fcfd507cae85f1a2e000000/Alvarez-Erviti-L-Seow-Y-Yin-H-Betts-C-Lakhal-S-and-Wood-MJA-Delivery-of-siRNA-to-the-mouse-brain-by-systemic-injection-of-targeted-exosomes-Nat-Biotechnol-29-341-345.pdf
Delivery of sirNA to the mouse brain by systemic ... we investigated the potential for exosome-mediated systemic siRNA delivery . ... of 5% glucose before intravenous injection in C57BL/6 mice. ...
https://www.ncbi.nlm.nih.gov/pubmed/?term=Delivery+of+siRNA+to+the+mouse+brain+by+systemic+injection+of+targeted+exosomes
1: Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Examples of anticipated results in which exosome-mediated siRNA delivery is evaluated by functional assays and imaging are also provided. ... L. et al. Delivery of siRNA to the mouse brain …Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://www.academia.edu/15139145/Delivery_of_siRNA_to_the_mouse_brain_by_systemic_injection_of_targeted_exosomes
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
https://reference.medscape.com/medline/abstract/21423189
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. ... To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be developed. Here we show that exosomes-endogenous nano-vesicles that transport RNAs and proteins-can deliver short interfering (si)RNA ...
https://www.researchgate.net/publication/50596721_Alvarez-Erviti_L_Seow_Y_Yin_H_Betts_C_Lakhal_S_and_Wood_MJA_Delivery_of_siRNA_to_the_mouse_brain_by_systemic_injection_of_targeted_exosomes_Nat_Biotechnol_29_341-345
Alvarez-Erviti, L, Seow, Y, Yin, H, Betts, C, Lakhal, S and Wood, MJA. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.
https://www.sigmaaldrich.com/catalog/papers/21423189
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. [Lydia Alvarez-Erviti, Yiqi Seow, Haifang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood] PMID 21423189 . Abstract To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be developed. Here we ...
https://www.sciencedirect.com/science/article/pii/S0168365918302190
Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease. ... , and delivery of BACE1 siRNA to the mouse brain by systemic injection. Nevertheless, for the BACE1 inhibition, only overcoming the BBB is insufficient.Author: Pengzhen Wang, Xiaoyao Zheng, Qian Guo, Peng Yang, Xiaoying Pang, Kang Qian, Wei Lu, Qizhi Zhang, Xi...
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