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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
The study demonstrates the efficacy of CPP conjugated siRNA duplexes in targeting primary neurons in vitro and the CNS tissue in vivo (however, this is via invasive administration of the siRNA directly to the brain tissue by convection enhanced delivery). The approach has minimal toxicity towards the targeted cells, in contrast to reported ...Author: Saroj P Mathupala
https://www.ncbi.nlm.nih.gov/pubmed/21423189
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Alvarez-Erviti L(1), Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Author information: (1)Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.sciencedirect.com/science/article/pii/S0142961213009848
The goal of the present study was to develop a novel, efficient brain delivery system composed of nucleic acids, such as siRNA. Therefore, we evaluated the delivery of siRNA to the brain following i.n. administration with a MPEG–PCL–Tat carrier.Author: T. Kanazawa, F. Akiyama, S. Kakizaki, Y. Takashima, Y. Seta
https://www.sciencedirect.com/science/article/pii/S0169409X07000221
The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Fig. 6, Fig. 7 demonstrate the delivery of PNA antisense agents to brain in vivo . siRNA duplexes can be monobiotinylated , which allows for high efficiency attachment to molecular Trojan horses using avidin–biotin ...Author: William M. Pardridge
https://www.future-science.com/doi/full/10.4155/tde.12.22
Mar 29, 2012 · If gene-silencing therapy in BCECs is actually demonstrated to be effective by in vivo delivery of siRNA in some disease models, research in this field is expected to be remarkably facilitated. We believe that techniques to deliver siRNA into BCECs could be further developed into techniques to deliver siRNA into the brain across the BBB.Author: Hiroya Kuwahara, Takanori Yokota, Hidehiro Mizusawa
https://altogen.com/InVivoTransfection3.pdf
Delivery of sirNA to the mouse brain by systemic injection of targeted exosomes Lydia Alvarez-Erviti1,2, Yiqi Seow 1,2, HaiFang Yin , Corinne Betts , Samira Lakhal 1 & Matthew J A Wood 1Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
https://www.precisionnanosystems.com/resource-center/publications/detail/lipid-nanoparticle-delivery-gene-silence-sirna-publication
siRNA-LNP can therefore be a highly potent gene delivery agent both for functional genome studies or development of new therapeutics for brain and neurological disorders. Abstract: Manipulation of gene expression in the brain is fundamental for understanding the function of proteins involved in …
https://www.cell.com/trends/biotechnology/pdf/S0167-7799(18)30027-1.pdf
Review Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy Meng Zheng,1 Wei Tao,2 Yan Zou,1 Omid C. Farokhzad,2 and Bingyang Shi1,* Small interfering RNA (siRNA)-based gene silencing technology has demon-
https://www.nature.com/articles/nature05901
Jun 17, 2007 · Because neurotropic viruses do cross the BBB to infect brain cells, we asked whether the strategy used by viruses to enter the central nervous system could also be …Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
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