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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The site of action of siRNA therapeutics is the cytosol. The barriers to siRNA delivery are multiple and depend on the targeted organs and the administration routes. In general, locoregional delivery of siRNA has fewer barriers compared to systemic delivery.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://link.springer.com/article/10.1208%2Fs12248-010-9210-4
Jun 11, 2010 · The three goals of this review were to provide an overview of (a) the barriers to siRNA delivery, from the perspectives of physicochemical properties of siRNA, pharmacokinetics and biodistribution, and intracellular trafficking; (b) the non-viral siRNA carriers including cell-penetrating peptides, polymers, dendrimers, siRNA bioconjugates,...Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://europepmc.org/articles/PMC2977003
Dec 01, 2010 · Barriers to systemic siRNA delivery. Barriers to distribution to the target organs include the degradation of siRNA and carriers, protein absorption (opsonization) and phagocytosis by mononuclear phagocyte system, and entrapment in reticuloendothelial system (RES). Barriers to extravasation and penetration in extracellular matrix are dependent on the physiological structure of …Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(17)30190-7
Diverse miRNA and siRNA molecule carriers have been suggested and developed differently that may have better stabilities and efficiencies with therapeutic RNA delivery systems. However, pharmaceutical companies need to apply these delivery systems to promote more efficient delivery of commercial therapeutic RNAs.Author: Chiranjib Chakraborty, Chiranjib Chakraborty, Ashish Ranjan Sharma, Garima Sharma, C. George Priya D...
https://www.slideshare.net/SamirPanchal1/barriers-and-carriers-for-sirna-delivery
Feb 19, 2013 · Barriers & Carriers for siRNA Delivery 2/19/2013 1 Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website.
https://www.sciencedirect.com/science/article/pii/S1931524419301458
Varied drug delivery platforms have been developed and widely investigated for siRNA delivery, including both viral and nonviral vectors. 16 Regarding the nonviral vectors, these delivery platforms have encompassed such technologies as lipid-based vectors, organic/inorganic nanovectors, nanogels, and peptide carriers. 16 Peptides, in particular, have received specific attention because they show …Author: James C. Cummings, Haiwen Zhang, Andrew Jakymiw
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946317/
Nov 18, 2015 · Local delivery of siRNA to bone In addition to the systemic administration of siRNA and its carrier, local delivery of siRNA directly to bone has also been explored. siRNA delivery system can be directly and specifically applied to different bone sites such as femur, vertebral spine, and wrist.Author: Xinli Liu
https://www.researchgate.net/publication/51414218_Drug_delivery_of_siRNA_therapeutics_potentials_and_limits_of_nanosystems
The inhalation route of administration provides local delivery of siRNA therapeutics to the lungs for various pulmonary diseases. A siRNA delivery system can be used to overcome the barriers of...
https://europepmc.org/articles/PMC4894740/
Jul 22, 2015 · Europe PMC is an archive of life sciences journal literature. Find the latest peer-reviewed research articles and preprints on Coronavirus here.Author: Arun R. Shrivats, Yuji Mishina, Saadyah Averick, Krzysztof Matyjaszewski, Jeffrey O. Hollinger
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