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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939975/
Jul 05, 2016 · This siRNA-based revolutionary approach can soon come to the market, depending on the results of several active Phase III clinical trials.5,6 This review will focus on siRNA delivery by lipid nanoparticles (LNPs) and the current status of clinical trials for these systems. In the first section, we will describe the different components forming ...Author: Timofei S Zatsepin, Yuri V Kotelevtsev, Victor Koteliansky
https://www.sciencedirect.com/science/article/pii/S0378517317302880
Quantitative monitoration of the disassembly of siRNA containing nanoparticles, even in full serum, should be considered when developing of siRNA polyplexes and other nanoparticulate nucleic acid delivery systems as well: the amount of siRNA still retained in the polyplexes in a particular medium will, in some extent, be predictive of the gene ...Author: Gennara Cavallaro, Carla Sardo, Emanuela Fabiola Craparo, Barbara Porsio, Gaetano Giammona
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964096/
Mar 18, 2014 · Nonetheless, the efficient, selective, and safe delivery of siRNA to hepatocytes is still a key challenge to the broad application of siRNA therapeutics to liver diseases . Biomimetic and bioinspired nanomaterials, such as exosomes and lipoprotein particles, have attracted extensive interest for a variety of applications including drug delivery ...Author: Yizhou Dong, Yizhou Dong, Kevin T. Love, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yu...
https://www.sciencedirect.com/science/article/pii/S0142961215005815
Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis Author links open overlay panel Jingga Morry a Worapol Ngamcherdtrakul a Shenda Gu a Shaun M. Goodyear a David J. Castro a b Moataz M. …Author: Jingga Morry, Worapol Ngamcherdtrakul, Shenda Gu, Shaun M. Goodyear, David J. Castro, Moataz M. Reda...
https://pubs.acs.org/doi/10.1021/nn502125h
Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. Journal of Controlled Release 2019, 295, 268-277. DOI: 10.1016/j.jconrel.2019.01.006. Dian-Jang Lee, Ernst Wagner.Author: Hyun Jin Kim, Hiroyasu Takemoto, Yu Yi, Meng Zheng, Yoshinori Maeda, Hiroyuki Chaya, Kotaro Hayashi,...
https://www.nature.com/articles/nnano.2012.73
In vivo, these nanoparticles showed a longer blood circulation time (t 1/2 ≈ 24.2 min) than the parent siRNA (t 1/2 ≈ 6 min). Access through your institution Buy or subscribeAuthor: Hyukjin Lee, Hyukjin Lee, Abigail K. R. Lytton-Jean, Yi Chen, Kevin T. Love, Angela I. Park, Emmanou...
https://pubs.acs.org/doi/abs/10.1021/nn101638u
Surface engineering of gold nanoparticles for in vitro siRNA delivery. Nanoscale 2012, 4 (16) , 5102. DOI: 10.1039/c2nr31290e. João Conde, Gonçalo Doria, Pedro Baptista. Noble Metal Nanoparticles Applications in Cancer. Journal of Drug Delivery 2012, 2012, 1-12. DOI: 10.1155/2012/751075.Author: Shutao Guo, Yuanyu Huang, Qiao Jiang, Yun Sun, Liandong Deng, Zicai Liang, Quan Du, Jinfeng Xing, Yu...
https://iopscience.iop.org/article/10.1088/1361-6528/ab313d
Jul 29, 2019 · The delivery of siRNA using polymeric-based nanoparticles (e.g. PEI) can exhibit severe toxicity towards different cell lines. It was found that the increasing the number of cationic groups or the concentration of the delivery system increased the toxicity level.Author: Waleed M. Hussein, Waleed M. Hussein, Yee S. Cheong, Chang Liu, Genan Liu, Anjuman Ara Begum, Maria ...
https://www.medscape.com/viewarticle/818963
Oct 25, 2019 · Lipid-based Nanoparticles for siRNA Delivery. Nanoplatforms have higher biocompatibility and lower toxicity in comparison with inorganic nanoparticles and viral vectors.
https://www.hindawi.com/journals/bmri/2013/782041/
Delivery systems can improve specificity of cancer cell targeting, prevent non-specific delivery of siRNA, and may also protect the siRNA during transport. Nanoparticles conjugated to the targeting ligand for effective siRNA delivery increase the chance of binding the tumor surface receptor; however, the process also increases the overall size ...Author: Jong-Min Lee, Tae-Jong Yoon, Young-Seok Cho
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