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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Lipid-based siRNA delivery systems include liposomes, micelles, microemulsions, and solid lipid nanoparticles . Liposomes are globular vesicles with an aqueous core and phospholipid bilayer, comprise natural body constituents (e.g., lipids, …Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · The use of small interfering RNAs (siRNAs) to induce gene silencing has opened a new avenue in drug discovery. However, their therapeutic potential is hampered by …Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in …Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684241/
Efficient peptide-mediated delivery of siRNA to the brain after iv injection relies on protecting the complex from serum nuclease and protease degradation en route. Liposomes are widely used as delivery vehicles for gene therapy products in in vitro assays. They are also being investigated for use in animal and human models as delivery vehicles for siRNA.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314441/
Jan 07, 2015 · The cytosolic delivery of siRNA resulted in highly efficient (90%) knockdown of a destabilized green fluorescence protein (deGFP) in deGFP-HEK293 cells. Moreover, the delivery of siRNA targeting polo-like kinase 1(siPLK1) silenced PLK1 expression in cancer cells, resulting in pronounced toxicity.Author: Ying Jiang, Rui Tang, Bradley Duncan, Ziwen Jiang, Bo Yan, Rubul Mout, Vincent M. Rotello
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Most siRNA delivery systems undergo cellular internalization through endocytosis. Various delivery systems aim to improve the rate of cellular uptake by incorporating targeting ligands that bind specifically to receptors on target cells to induce receptor-mediated endocytosis .Author: Cong-fei Xu, Jun Wang
https://www.ncbi.nlm.nih.gov/pubmed/21423189
The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in …Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542916/
Mar 30, 2017 · For targeted delivery of siRNAs to hepatocytes, Rozema et al. have developed a polymer-siRNA conjugate delivery system termed Dynamic PolyConjugates (DPCs) . Recently, siRNA conjugates have shown promise as delivery platforms, leading to the development of well-defined, single-component systems that optimize the usage of minimal amounts of delivery material [ 131 - 134 ].Author: Hassan Dana, Ghanbar Mahmoodi Chalbatani, Habibollah Mahmoodzadeh, Rezvan Karimloo, Omid Rezaiean, A...
https://www.nature.com/articles/nature05901
Jun 17, 2007 · Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain. This 29-amino-acid peptide...Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
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