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https://cbe.statler.wvu.edu/files/d/b6d446ff-6b71-4e04-ae5d-ec285424f6c8/transdermal.pdf
Design and Production of a Transdermal Delivery Device for Contraception Introduction In this project, a transdermal drug delivery system for a generic version of the birth-control device Ortho-Evra® was designed. Transdermal systems deliver a slow release of drug into the body over time, resulting in long-term effectiveness and added convenience.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700785/
Today, there are 19 transdermal delivery systems for such drugs as estradiol, fentanyl, lidocaine and testosterone; combination patches containing more than one drug for contraception and hormone replacement; and iontophoretic and ultrasonic delivery systems for analgesia (Table 1, Fig. 1). Between 1979 and 2002, a new patch was approved on average every 2.2 years.Author: Mark R Prausnitz, Robert Langer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403087/
Mar 18, 2015 · The development of adhesive transdermal delivery devices. Dale Wurster's contribution to the early understanding of transdermal delivery is seldom acknowledged (Roberts, 2013). Important components of that work, often associated with transdermal delivery, are the defined delivery system in dose, area, vehicle and device; the quantification of the time course of absorption into urine; and the application of pharmacokinetic principles to quantify the resulting drug delivery kinetics.Author: Michael N Pastore, Yogeshvar N Kalia, Michael Horstmann, Michael S Roberts, Michael S Roberts
https://www.fdanews.com/ext/resources/files/2019/11-20-19-TDSdraftguidance.pdf?1574288455
Topically administered liquid and semi-solid drug products without a carrier device (e.g., gels, creams, lotions, foams, ointments, or sprays) are not considered to be TDS and are not covered by this guidance, even though they can be formulated to provide local, or in some cases, transdermal delivery of the drug.
https://www.sciencedirect.com/science/article/pii/S0169409X17301801
Transdermal drug delivery is a prospective drug delivery strategy to complement the limitations of conventional drug delivery systems including oral and injectable methods. This delivery route allows both convenient and painless drug delivery and a sustained release profile with reduced side effects.Author: Hyunjae Lee, Changyeong Song, Seungmin Baik, Dokyoon Kim, Taeghwan Hyeon, Dae-Hyeong Kim
https://www.sciencedirect.com/science/article/pii/S0168365919301609
Finally, implanted contraceptive hormonal devices, such as intrauterine devices and subdermal rods, can last for many years after administration by a healthcare professional. These methods have the same failure rates in perfect use and typical use (0.05–0.2% failure rates), indicating that the very infrequent need to have these contraceptives administered significantly improves adherence.Author: Mohammad Mofidfar, Laura O'Farrell, Mark R. Prausnitz
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