We have collected information about Delivery Of Poorly Soluble Or Poorly Permeable Drugs for you. Follow the links to find out details on Delivery Of Poorly Soluble Or Poorly Permeable Drugs.
https://www.sciencedirect.com/science/article/pii/B9780128177785000087
The advantages of microemulsions in oral delivery of poorly soluble drugs include good adherence to the GIT membranes as a result of small droplet size, drug protection against enzymatic hydrolysis, and the potential for enhanced absorption due to a surfactant-induced changes in the membrane fluidity and increment in permeability , .Author: Anđelka B. Kovačević
https://technology-catalysts.com/multi-client-report/delivery-of-poorly-soluble-or-poorly-permeable-drugs-7th-edition/
Delivery of Poorly Soluble or Poorly Permeable Drugs – 7th Edition Publication Date: July 2014 Bioavailability problems are common in the pharmaceutical industry and often cause delays in drug development. Poor bioavailability is a major reason for failure of drugs in preclinical development.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629443/
Aug 24, 2015 · Liposomal drug delivery offer significant therapeutic benefits to poorly soluble compounds. One such example is the formulation of cyclosporine and paclitaxel in which surfactants and organic co-solvents are used for systemic administration in humans.Author: Sandeep Kalepu, Vijaykumar Nekkanti
https://www.sciencedirect.com/science/article/pii/S0163782717300401
The loading of poorly water-soluble (and poorly permeable) drugs into drug delivery systems is aimed at improving their solubility thereby increasing their bioavailability. Delivery systems based on lipid raw materials meet these demands, while they are tailored for a set of administration routes (e.g. topical, oral, pulmonary, or parenteral).Author: M.C. Teixeira, C. Carbone, C. Carbone, E.B. Souto
https://www.sciencedirect.com/science/article/pii/S0928098719302301
Poorly water-soluble drugs present ongoing challenges with their translation into viable medicinal products. The hurdles to their successful oral delivery are a complex web of physical-chemical, biological, physiological and anatomical factors that act independently and in concert to limit drug bioavailability.Author: Ben J. Boyd, Christel A.S. Bergström, Zahari Vinarov, Martin Kuentz, Joachim Brouwers, Patrick Augus...
https://www.intecpharma.com/technology/poorly-soluble-drugs/
According to the AAPS Journal published by the American Association of Pharmaceutical Scientists, approximately 40% of top 200 major market oral drugs are poorly soluble (BCS Class II or Class IV). Further, according to the Drug Development & Delivery Journal , approximately 90% of new chemical entities (NCEs) in development were either BCS Class II or Class IV drugs.
https://www.pharmafocusasia.com/articles/enhancement-of-the-aqueous-solubility-and-permeability
CDs enhance bioavailability of poorly water-soluble drugs by increasing drug solubility, dissolution and permeability by making the drug available at the surface of the biological barrier (e.g., skin and mucosa) to partition into the membrane without disrupting the lipid layers (Loftsson and Stefansson, 1997).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326160/
Mar 06, 2012 · The use of surfactants has long been a primary drug delivery strategy to increase the apparent aqueous solubility of lipophilic drugs. Indeed, surfactants often play a crucial role in providing the solubilization power to enable the oral absorption of poorly soluble drugs that otherwise could not be delivered.Author: Arik Dahan, Jonathan M. Miller
https://www.sciencedirect.com/science/article/pii/S2211383515001069
In order to gain marketing exclusivity and patent protection for such products, revitalization of poorly soluble drugs using insoluble drug delivery technologies have been successfully adopted by many pharmaceutical companies. This review covers the recent advances in the field of insoluble drug delivery and business prospects.Author: Sandeep Kalepu, Vijaykumar Nekkanti
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399483/
Jul 05, 2012 · The poor solubility and low dissolution rate of poorly water soluble drugs in the aqueous gastrointestinal fluids often cause insufficient bioavailability. Especially for class II (low solubility and high permeability) substances according to the BCS, the bioavailability may be enhanced by increasing the solubility and dissolution rate of the drug in the gastro-intestinal fluids.Author: Ketan T. Savjani, Anuradha K. Gajjar, Jignasa K. Savjani
Searching for Delivery Of Poorly Soluble Or Poorly Permeable Drugs?
You can just click the links above. The data is collected for you.
