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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629443/
Aug 24, 2015 · Liposomal drug delivery offer significant therapeutic benefits to poorly soluble compounds. One such example is the formulation of cyclosporine and paclitaxel in which surfactants and organic co-solvents are used for systemic administration in humans. These solubilizers may cause toxicity at the administered doses.Author: Sandeep Kalepu, Vijaykumar Nekkanti
https://www.sciencedirect.com/science/article/pii/S0928098719302301
Poorly water-soluble drugs present ongoing challenges with their translation into viable medicinal products. The hurdles to their successful oral delivery are a complex web of physical-chemical, biological, physiological and anatomical factors that act independently and in concert to limit drug bioavailability.Author: Ben J. Boyd, Christel A.S. Bergström, Zahari Vinarov, Martin Kuentz, Joachim Brouwers, Patrick Augus...
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118444726
Jan 21, 2013 · Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug …
https://www.mdpi.com/1999-4923/11/6/269
Delivery of Poorly Soluble Drugs via Mesoporous Silica: Impact of Drug Overloading on Release and Thermal Profiles . by Tuan-Tu Le, Abdul Khaliq Elzhry Elyafi, Afzal R. Mohammed and Ali Al-Khattawi * Aston Pharmacy School, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK *Author: Tuan-tu Le, Abdul Khaliq Elzhry Elyafi, Afzal-Ur-Rahman Mohammed, Ali Al-Khattawi
https://www.pharmaexcipients.com/oral-excipients/mesoporous-silica-drug-delivery/
Delivery of Poorly Soluble Drugs via Mesoporous Silica The most important properties of promising drug candidates for oral dosage form are aqueous solubility and intestinal permeability. Over 40% of drugs on the market are BCS class II and IV, which have low solubility.
https://www.hindawi.com/journals/jnm/2015/216375/
Poor aqueous solubility of some drug molecules is a major problem in drug formulation. Drug nanosuspensions emerged as one solution to delivering such hydrophobic drugs. Scaling down to nanoparticles enhances drug aqueous solubility and bioavailability by increasing drug surface area that comes into contact with biological media.Author: Roya Yadollahi, Krasimir Vasilev, Spomenka Simovic
https://www.intecpharma.com/technology/poorly-soluble-drugs/
Bioavailability of Poorly Soluble Drugs: a Challenge for the Pharmaceutical Industry. According to the AAPS Journal published by the American Association of Pharmaceutical Scientists, approximately 40% of top 200 major market oral drugs are poorly soluble (BCS Class II or Class IV). Further, according to the Drug Development & Delivery Journal, approximately 90% of new chemical entities (NCEs ...
https://www.sciencedirect.com/science/article/pii/S2211383515001069
Solid lipid nanoparticles (SLN) are promising drug carriers with potential applications in the delivery of poorly soluble drugs82, 83. The lipid excipients used in the SLN formulations are biocompatible and biodegradable and most of them are physiological components that …Author: Sandeep Kalepu, Vijaykumar Nekkanti
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888743/
Dec 26, 2013 · In some investigations, solid self-emulsifying drug delivery systems (solid-SEDDS) were prepared by means of a wet granulation process in a lab-scale high shear mixer in order to improve the dissolution rate of a poorly water-soluble drug.Author: Shweta Gupta, Rajesh Kesarla, Abdelwahab Omri
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