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https://www.sciencedirect.com/science/article/pii/S0169409X11002900
Nanocarriers are an emerging class of drug delivery systems that can be easily tailored to delivery drugs to various parts of the body, including the brain. In the past decade, it has been attracting increasing attention for its use in transport of drug across the BBB due to the rapid increase in our understanding of receptors and the fast development in polymer chemistry and nanotechnology.Author: Yan Chen, Lihong Liu
https://www.sciencedaily.com/releases/2019/09/190924101450.htm
Sep 24, 2019 · The blood-brain barrier (BBB) regulates the delivery of all substances from the blood circulation into the brain. Its main function is to protect the central nervous system (CNS) from harmful...
https://www.biopharma-reporter.com/Article/2019/01/21/Drug-delivery-of-biologics-to-the-brain
Jan 21, 2019 · ‘A relatively small footprint’: Drug delivery for biologics to the brain. Reaching the central nervous system is a difficult task, and getting a high enough dose to it poses an issue as well, but innovations are well underway to bridge a path across the blood-brain barrier.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2469271/
Dec 05, 2007 · INTRODUCTION. For central drug effects to occur, the drug must first be delivered to the brain. Because of the properties of the blood–brain barrier (BBB), researchers accept a high likelihood of failure when developing drugs for brain delivery (1,2).Methods for investigating drug candidates in this field, from in vitro to in situ and in vivo, are under evaluation (1,3–13).Author: Margareta Hammarlund-Udenaes, Markus Fridén, Markus Fridén, Stina Syvänen, Stina Syvänen, Anubha Gup...
https://pubs.rsc.org/en/content/articlelanding/2019/nr/c9nr02876e
While new brain tumor cell-specific drugs are continuously becoming available, efficient drug delivery to brain tumors remains a limiting factor. We developed a multicomponent nanoparticle, consisting of an iron oxide core and a mesoporous silica shell that can effectively deliver drugs across the blood–brain barrier into glioma cells.Author: O. Turan, P. Bielecki, V. Perera, M. Lorkowski, G. Covarrubias, K. Tong, A. Yun, A. Rahmy, T. Ouyang...
https://www.ncbi.nlm.nih.gov/pubmed/15681025
Why does the rapid delivery of drugs to the brain promote addiction? Samaha AN(1), Robinson TE. Author information: (1)Department of Psychology (Biopsychology Program), University of Michigan, Ann Arbor, MI 48109-1109, USA. It is widely accepted that the more rapidly drugs of abuse reach the brain the greater their potential for addiction.Author: Anne Noël Samaha, Terry E. Robinson
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Delivering drugs into the brain is critical to the successful treatment of certain diseases such as brain tumors, Alzheimer’s disease, and Parkinson’s disease, but better methods are needed to cross or bypass the BBB.
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