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https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-1154-7
Apr 05, 2019 · Until now, only one therapeutic cancer vaccine has been approved for human use (DC cancer vaccine, Sipuleucel T) [], and most of the other cancer vaccines, including DNA vaccines, are still in clinical phase I or II.New developments in plasmid delivery and optimization and the combination with other therapies aim to improve the efficacy of DNA vaccines in preclinical and clinical studies to ...Author: Alessandra Lopes, Gaëlle Vandermeulen, Véronique Préat
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109217/
Specifially, Ottensmeier et al reported results from a prostate cancer DNA vaccine study where they detected IFN-γ producing CD8+ T-cells against the target PSMA peptide in approximately 60% of the cases and that EP delivery of DNA stimulated T-cell responses more quickly and with a greater magnitude compared to the cohort that received the ...Author: Niranjan Y Sardesai, David B Weiner
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721783/
Jul 24, 2019 · Cancer vaccines or immunotherapeutics are increasingly recognized as key approaches against cancer. In the last two decades, a number of methods of antigen delivery have been developed, some of which have shown strong anti-tumor immune responses and clinical responses in humans (Figure 1).The combination of immune checkpoints and immune cell therapies has refocused our …Author: Vasso Apostolopoulos
https://www.hindawi.com/journals/bmri/2010/174378/
Due to their rapid and widespread development, DNA vaccines have entered into a variety of human clinical trials for vaccines against various diseases including cancer. Evidence that DNA vaccines are well tolerated and have an excellent safety profile proved to be of advantage as many clinical trials combines the first phase with the second, saving both time and money. It is clear from the ...Author: Daniela Fioretti, Sandra Iurescia, Vito Michele Fazio, Monica Rinaldi
https://www.creative-biolabs.com/vaccine/dna-based-cancer-vaccines.htm
DNA Based Cancer Vaccines. Nucleic acid immunization has garnered much attention as a promising approach for cancer therapeutic development. This innovative vaccine strategy uses non-live, non-replicating, non-spreading DNA formulations which utilize the host’s cellular machinery for expression of proteins (antigens).
https://medicalxpress.com/news/2015-04-nanoparticle-coated-bacteria-cancer-vaccine.html
Apr 16, 2015 · Marking an important step in the development of immunotherapy cancer treatment, scientists have demonstrated that nanoparticle-coated bacteria can effectively deliver an oral DNA …
https://www.nature.com/articles/nrd.2017.243
Jan 12, 2018 · Table 3 Clinical trials with mRNA vaccines against cancer. ... J. A. & Schmaljohn, C. S. Advancements in DNA vaccine vectors, non-mechanical delivery methods, and …Author: Norbert Pardi, Michael J. Hogan, Frederick W. Porter, Drew Weissman
https://www.sciencedirect.com/topics/immunology-and-microbiology/rna-vaccine
The main difference between DNA and RNA vaccines and virus-vectored vaccines is the complexity of the delivery system, which in the case of virus-vectored vaccines (recombinant attenuated virus expressing vaccine antigen), as the most complex system, …
https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/cancer-vaccines.html
Once the vaccine is ready, it’s injected into the body to increase the immune response against cancer cells. Vaccines are often combined with other substances or cells called adjuvants that help boost the immune response even further. Cancer vaccines cause the immune system to attack cells with one or more specific antigens.
https://www.sciencedirect.com/book/9780128140390/vaccines-for-cancer-immunotherapy
Cancer vaccines, which are a type of immunotherapeutic agents, have been widely studied for prevention and treatment of tumors. Therapeutic cancer vaccines improve patient's immune response against tumor cells. One of the several types of cancer vaccines is whole tumor cell vaccine.
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