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https://www.sciencedirect.com/science/article/pii/S0928098710000631
DNA-based vaccine directed to tumor-specific antigens is an attractive strategy in cancer prevention and therapy. In view of the poor immunogenicity of most tumor-associated antigens, studies were carried out here to examine the adjuvant effect of polyethylenimine (PEI), a cationic polymer widely used in non-viral gene delivery, on the efficacy of cancer vaccine strategy.Author: Yi-Fan Ma, Ya-Wun Yang
https://www.researchgate.net/publication/42371010_Delivery_of_DNA-based_cancer_vaccine_with_polyethylenimine
The intracellular co-delivery of protein and plasmid DNA vaccines was significantly higher for mPEI-based triple nanocomplexes than for a simple physical mixture of the proteins and DNA.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260377/
Jan 10, 2012 · The extent of bystander cell death in vivo may also need to be fine-tuned through polymer-mediated co-delivery of cytotoxic agents 37 or cell death inhibitors 38 along with the DNA vaccine. Finally, the optimal route of administration 39,40 of the polymer-DNA vaccine needs to be identified to maximize the potential benefit of bystander cell targeting.Author: R. Noelle Palumbo, Xiao Zhong, Chun Wang
https://onlinelibrary.wiley.com/doi/full/10.1002/jgm.173
You-Kyoung Kim, Lei Xing, Bao-An Chen, Fengguo Xu, Hu-Lin Jiang and Can Zhang, Aerosol delivery of programmed cell death protein 4 using polysorbitol-based gene delivery system for lung cancer therapy, Journal of Drug Targeting, 10.3109/1061186X.2014.932796, 22, 9, (829-838), (2014).Author: Antoine Kichler, Christian Leborgne, Emmanuel Coeytaux, Olivier Danos
https://www.sciencedirect.com/science/article/pii/S1549963415002038
Therefore, polyethylenimine (PEI)-based polyplexes were assessed for delivery of RepRNA encoding influenza virus hemagglutinin and nucleocapsid. Polyplex-formulation protected the RepRNA and promoted an efficient intracellular delivery to DCs, leading to RepRNA translation.Author: Thomas Démoulins, Panagiota Milona, Pavlos C. Englezou, Thomas Ebensen, Kai Schulze, Rolf Suter, Cha...
https://www.sciencedirect.com/science/article/pii/S0142961211002444
Various approaches to improve the immunogenicity of DNA vaccines have been investigated, including DNA vaccine delivery systems and co-delivery with protein antigens,,. Among the DNA vaccine delivery systems investigated to date are cationic nonviral carriers such as polyethylenimine (PEI), chitosan, and cationic liposomes.Author: Hee Jeong Cho, Su Eun Han, Saewon Im, Youngsik Lee, Young Bong Kim, Taehoon Chun, Yu Kyoung Oh
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