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https://www.nature.com/articles/7700011
Oct 22, 1999 · One novel approach to combat prostate cancer is gene therapy. A replication-deficient recombinant adenoviral vector (AdRSVlacZ) expressing bacterial β-galactosidase (β-gal) (lacZ) under the control...Author: Yi Lu, John Carraher, Yu Zhang, Jianling Armstrong, Jody Lerner, William P Rogers, Mitchell S Steine...
https://www.ncbi.nlm.nih.gov/pubmed/10078965
One novel approach to combat prostate cancer is gene therapy. A replication-deficient recombinant adenoviral vector (AdRSVlacZ) expressing bacterial beta-galactosidase (beta-gal) (lacZ) under the control of the Rous sarcoma virus promoter was used to determine which delivery route was best for the transduction of adenoviral vectors to the prostate.Author: Yi Lu, John Carraher, Yu Zhang, Jianling Armstrong, Jody Lerner, William P Rogers, Mitchell S Steine...
https://www.researchgate.net/profile/Mitchell_Steiner/publication/13211929_Delivery_of_adenoviral_vectors_to_the_prostate_for_gene_therapy/links/5564020608ae6f4dcc98bdfe.pdf?inViewer=0&pdfJsDownload=0&origin=publication_detail
approach to combat prostate cancer is gene therapy. A replication-deficient recombinant adenoviral vector (AdRSVlacZ) expressing bacterial b-galactosidase (b-gal) (lacZ) under the control of the...
https://www.researchgate.net/publication/13211929_Delivery_of_adenoviral_vectors_to_the_prostate_for_gene_therapy
Prostate cancer has become the most frequently occurring cancer and the second leading cause of cancer deaths in men. One novel approach to combat prostate cancer is gene therapy. A replication-deficient recombinant adenoviral vector (AdRSVlacZ) expressing bacterial beta-galactosidase...
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1268-z
Jun 25, 2019 · To obtain optimum delivery and maximum antitumor effects of these adenoviral vectors, we have developed a novel vehicle system for adenoviral vectors delivery by equipping human mesenchymal stem (stromal) cells (MSCs) with adenovirus (type C) E1A/B (E1s) genes. These genes are vital for the replication of adenoviruses.Author: Tahir Muhammad, Ali Sakhawat, Aamir Ali Khan, Ling Ma, Ruth A. Gjerset, Yinghui Huang
https://stemcellres.biomedcentral.com/track/pdf/10.1186/s13287-019-1268-z
Fig. 2 Apoptosis induced by CRAd and Adbic in prostate tumor cells. a Flow cytometry analysis by FASCcalibur. Prostate tumor cells stained with. Annexin V-FITC/Propidium iodide stains after 48h of treatment with CRAd and Adbic adenoviral vectors at 100 MOI.Author: Tahir Muhammad, Ali Sakhawat, Aamir Ali Khan, Ling Ma, Ruth A. Gjerset, Yinghui Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550784/
Adenoviral Gene Therapy Vectors. First-generation adenoviral vectors are replication attenuated by removal of the E1A gene (Figure 3). 19 Without the E1A gene, viral genes are not expressed at high enough levels for effective replication and packaging, leaving the recombinant virus as a simple carrier of therapeutic genes. Recombinant ...Author: Shawn E Lupold, Ronald Rodriguez
http://www.genetherapyreview.com/disease-targets/cancer/targeted-prostate-cancer-gene-therapy
However, for locally advanced prostate cancer, variations in delivery strategy may help to target gene therapy vectors to the prostate. We have conducted a study of comparison of effectiveness of gene transfer by adenoviral vectors to the prostate by three different delivery routes …
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