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https://link.springer.com/protocol/10.1385%2F1-59259-650-9%3A37
Abstract. The liver represents a major target organ for gene delivery owing to its high biosynthetic capacity and access to the bloodstream. Adenoviral vectors are highly efficient gene-transfer vehicles, making them among the most promising systems for in vivo gene transfer to the liver.Author: Sheila Connelly, Christine Mech
https://www.researchgate.net/publication/7405897_Delivery_of_adenoviral_DNA_to_mouse_liver
Request PDF Delivery of adenoviral DNA to mouse liver The liver represents a major target organ for gene delivery owing to its high biosynthetic capacity and access to the bloodstream.
https://www.ncbi.nlm.nih.gov/pubmed/14970584
Delivery of adenoviral DNA to mouse liver. Connelly S(1), Mech C. Author information: (1)Advanced Vision Therapies Inc., Rockville, MD, USA. The liver represents a major target organ for gene delivery owing to its high biosynthetic capacity and access to the bloodstream.Author: Sheila Connelly, Christine Mech
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083003/
Sep 07, 2018 · Delivery of genes to mouse liver is routinely accomplished by tail-vein injections of viral vectors or naked plasmid DNA. While viral vectors are typically injected in a low-pressure and -volume fashion, uptake of naked plasmid DNA to hepatocytes is facilitated by high pressure and volumes, also known as hydrodynamic delivery.Author: Trine Dalsgaard, Claudia R. Cecchi, Anne Louise Askou, Rasmus O. Bak, Pernille O. Andersen, David Ho...
https://www.liebertpub.com/doi/10.1089/hum.2019.127
Dec 16, 2019 · The right kidney of the SC injected mouse also shows some transduction of tubule cells, some of which coincide with PT marker (lower yellow arrow) and some of which are likely distal tubule or collecting duct cells (upper yellow arrow). Liver sections from the RU and SC injected mice corroborate leakage of the vector to the liver.Author: Jeffrey D. Rubin, Tien V. Nguyen, Kari L. Allen, Katayoun Ayasoufi, Michael A. Barry
https://www.sciencedirect.com/science/article/pii/S0014579314006838
Adenoviral delivery of CRISPR/Cas9 produces efficient gene editing in cultured cells. • Effective gene knockout in the adult mouse liver via adenoviral delivery of CRISPR/Cas9. • The gene editing in the liver is stable over long term and after extensive liver tissue regeneration.Author: Ranran Cheng, Jin Peng, Yonghong Yan, Peili Cao, Jiewei Wang, Chen Qiu, Lichun Tang, Di Liu, Li Tang...
https://www.liebertpub.com/doi/abs/10.1089/hum.1996.7.13-1555
The utility of transient immune modulation is evaluated in mouse models of lung- and liver-directed gene transfer. ... Long-term Transgene Expression from Plasmid DNA Gene Therapy Vectors Is Negatively Affected by CpG Dinucleotides ... Restoration of the Ability to Generate CTL in Mice Immune to Adenovirus by Delivery of Virus in a Collagen ...Author: Karin Jooss, Yiping Yang, James M. Wilson
https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2014.09.008
Having demonstrated the efficiency of AdenoCas9, we wanted to test it in adult mouse liver which is susceptible to adenovirus infection. We chose Cebpα as the target. Cebpα was among the transcription factors identified in our liver proteome project to be systematically screened for their functions in the liver. It was chosen because the ...Author: Ranran Cheng, Jin Peng, Yonghong Yan, Peili Cao, Jiewei Wang, Chen Qiu, Lichun Tang, Di Liu, Li Tang...
https://www.researchgate.net/publication/330773046_AAV-Mediated_Gene_Delivery_to_the_Mouse_Liver_Universitatsfrauenklinik_Heidelberg
The liver is an attractive target for gene therapy due to the high incidence of liver disease phenotypes. Adeno-associated viral vectors (AAV) are currently the most popular gene delivery system ...
https://www.nature.com/articles/s41467-017-02707-6
Jan 31, 2018 · Shield reduces viral gene delivery to liver and spleen. ... N. et al. Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav ...Author: Markus Schmid, Patrick Ernst, Annemarie Honegger, Maarit Suomalainen, Martina Zimmermann, Lukas Brau...
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