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https://www.biopharma-reporter.com/Article/2019/01/21/Drug-delivery-of-biologics-to-the-brain
Jan 21, 2019 · ‘A relatively small footprint’: Drug delivery for biologics to the brain. Reaching the central nervous system is a difficult task, and getting a high enough dose to it poses an issue as well, but innovations are well underway to bridge a path across the blood-brain barrier.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998643/
In brain cancer, the situation is complicated by the blood-brain barrier (BBB) and blood–cerebrospinal fluid barrier, which serve as physical and physiologic obstacles for delivery of drugs …Author: Jaishri Blakeley
https://pubs.rsc.org/en/content/articlelanding/2019/nr/c9nr02876e
While new brain tumor cell-specific drugs are continuously becoming available, efficient drug delivery to brain tumors remains a limiting factor. We developed a multicomponent nanoparticle, consisting of an iron oxide core and a mesoporous silica shell that can effectively deliver drugs across the blood–brain barrier into glioma cells.Author: O. Turan, P. Bielecki, V. Perera, M. Lorkowski, G. Covarrubias, K. Tong, A. Yun, A. Rahmy, T. Ouyang...
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Although the BBB limits the delivery of certain drugs to the brain and, as such, hampers the treatment of certain CNS disorders, accessing the brain via the nose-to-brain route has been demonstrated by scores of preclinical studies and about a dozen clinical trial results.Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
Nanocarriers are an emerging class of drug delivery systems that can be easily tailored to delivery drugs to various parts of the body, including the brain. In the past decade, it has been attracting increasing attention for its use in transport of drug across the BBB due to the rapid increase in our understanding of receptors and the fast development in polymer chemistry and nanotechnology.Author: Yan Chen, Lihong Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409749/
Feb 17, 2019 · Nose-to-brain drug delivery is a painless, non-invasive administration route that can be used to deliver therapeutic agents into the brain by bypassing the BBB [10,14,15,16,17]. These drug administration pathways are characterized by many advantages such as increased patient compliance, high safety, remarkable ease of administration and rapid onset of action, as well as minimized …Author: Maria Cristina Bonferoni, Silvia Rossi, Giuseppina Sandri, Franca Ferrari, Elisabetta Gavini, Giovan...
https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/
As previously discussed, the physicochemical properties of drugs, such as the molecular weight and lipophilicity, are critical parameters that have the most influence …
https://www.sciencedirect.com/science/article/pii/S0168365916303236
However, the delivery of several of these drugs to the brain parenchyma may also be reduced by ATP-binding cassette transporters (ABCs), which are active efflux pumps that transport possibly neurotoxic lipid-soluble molecules or other pharmaceutic drugs into the blood . A deeper knowledge regarding the mechanisms of passage across this highly selective barrier will foster the development of new strategies for the delivery …Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
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