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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604883/
Dec 10, 2008 · Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central ...Author: Leah R Hanson, William H Frey, William H Frey
http://intranasal.net/Overview/default.htm
Drug volume discussion. The volume of drug administered is a poorly studied but important clinical concept for those who are interested in a deeper understanding of intranasal medication delivery and the pharmaceutical/FDA approach to dosing and concentration versus the approach of clinicians who just want to help their patients.
https://www.celerion.com/wp-content/uploads/2015/05/Celerion_050515_TIDES_Intranasal-Drug-Delivery.pdf
(2012) Drug development of intranasally delivered peptides. Therapeutic Delivery 3(4), 557-568 Dhuria SV, Hanson LR, Frey WH, 2nd (2010) Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99(4), 1654-1673 Merkus FW, Van Den Berg MP (2007) Can nasal drug deliveryFile Size: 1MB
https://www.ncbi.nlm.nih.gov/pubmed/29277310
Feb 15, 2018 · The intranasal route is composed of two pathways, one being intracellular while the other being extracellular. The intracellular pathway begins with endocytosis by olfactory sensory cells, followed by axonal transport to their synaptic clefts in the olfactory bulb where the drug is exocytosed.Author: Tyler P. Crowe, M. Heather West Greenlee, Anumantha G. Kanthasamy, Walter H. Hsu
https://www.businesswire.com/news/home/20190813005289/en/Global-Intranasal-Drug-Delivery-Market-Report-2019
Aug 13, 2019 · Global Intranasal Drug Delivery Market Report 2019: Analysis, Trends, and Forecasts 2016-2024 - Focus on Allergic Infections, Analgesics, Osteoporosis, Vaccinations - ResearchAndMarkets.com
https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
become the dominant delivery principle in nasal drug delivery. Direct-Haler is the first drug deliv-ery company to take advantage of this device-dependent reflex for enhancing nasal drug deliv-ery. Naturally, the increased interest in this princi-ple for enhanced nasal delivery has recently led other companies to seek exploitation of the same
http://intranasal.net/DeliveryTechniques/default.htm
Squeeze bottle delivery is another option for nasal drug delivery. However this technique is not able to deliver a measure dose of drug. Mucosal coverage is also dependent on the patient applying adequate pressure to the device to deliver the drug - so delivery is very variable.
https://www.sciencedirect.com/science/article/pii/S0361923018303678
After this introductory part various in vitro, ex vivo and in vivo models for investigation of intranasal drug delivery will be presented based on the latest literature of the field. Then some studies which evaluate the intranasal penetration of drugs for different CNS indications will be shown.Author: Franciska Erdő, Luca Anna Bors, Dániel Farkas, Ágnes Bajza, Sveinbjörn Gizurarson
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