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http://www.vetmed.vt.edu/clinical-trials/canine-glioma/convection-enhanced-delivery.asp
Convection Enhanced Delivery (CED) is a therapeutic strategy that was developed to facilitate targeted delivery of pharmaceuticals to the brain. The CED procedure involves a minimally invasive surgical exposure of the brain, followed by placement of small diameter catheters directly into the brain tumor. Subsequently, infusion of therapeutics ...
https://braintumorcenter.ucsf.edu/treatment/experimental-diagnostics-therapies/convection-enhanced-delivery
Increasing dosages would not work either, since these medications would reach toxic concentrations in the body before reaching effective concentrations in the brain. To address this problem, researchers at UCSF and elsewhere have been developing a procedure called convection-enhanced delivery (CED). CED is an experimental technique for directly infusing drugs into a brain tumor.
https://www.ncbi.nlm.nih.gov/pubmed/19831841
The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment.Author: Waldemar Debinski, Stephen B Tatter
https://link.springer.com/article/10.1007/s13311-017-0520-4
Mar 15, 2017 · Convection-enhanced delivery (CED) is a promising technique that generates a pressure gradient at the tip of an infusion catheter to deliver therapeutics directly through the interstitial spaces of the central nervous system. It addresses and offers solutions to many limitations of conventional techniques, allowing for delivery past the blood–brain barrier in a targeted and safe manner that ...Author: A. M. Mehta, A. M. Sonabend, J. N. Bruce
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30322-X/fulltext
Convection-enhanced delivery in the brainstem of children with diffuse intrinsic pontine glioma who have previously received radiation therapy seems to be a rational and safe therapeutic strategy. PET-based dosimetry of the radiolabelled antibody [124I]-8H9 validated the principle of using convection-enhanced delivery in the brain to achieve high intra-lesional dosing with negligible systemic ...Author: Mark M Souweidane, Mark M Souweidane, Kim Kramer, Kim Kramer, Neeta Pandit-Taskar, Neeta Pandit-Task...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657605/
Convection-enhanced delivery to brain parenchyma. Accessibility of pharmacological agents from the bloodstream to the CNS meets with a formidable obstacle in the form of the BBB [].There is an absence of direct intracranial administration-only agents that are actively transported through the BBB or that are otherwise permeable through the barrier, which can directly kill tumor cells.Author: Waldemar Debinski, Stephen B Tatter
https://www.medscape.com/viewarticle/712531
Nov 06, 2019 · The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has …
http://www.aetna.com/cpb/medical/data/700_799/0731.html
Convection-enhanced delivery of fluorescent nanoparticles indicated that particles co-localize with peri-vascular basement membranes throughout the striatum but, unlike soluble dextrans, are not taken up by peri-vascular macrophages after 3 hrs.
https://www.frontiersin.org/articles/10.3389/fonc.2019.00966/full
Convection-enhanced delivery (CED) is a method used to increase transport of therapeutics in and around brain tumors. CED works through locally applying a pressure differential to drive fluid flow throughout the tumor, such that convective forces dominate over diffusive transport. This allows therapies to bypass the blood brain barrier that would otherwise be too large or solely rely on ...Author: Caleb A. Stine, Jennifer M. Munson
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