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https://www.vetmed.vt.edu/clinical-trials/canine-glioma/convection-enhanced-delivery.asp
Convection Enhanced Delivery (CED) is a therapeutic strategy that was developed to facilitate targeted delivery of pharmaceuticals to the brain. The CED procedure involves a minimally invasive surgical exposure of the brain, followed by placement of small diameter catheters directly into the brain tumor. Subsequently, infusion of therapeutics ...
https://www.ncbi.nlm.nih.gov/pubmed/19831841
The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment.Author: Waldemar Debinski, Stephen B Tatter
https://braintumorcenter.ucsf.edu/treatment/experimental-diagnostics-therapies/convection-enhanced-delivery
Increasing dosages would not work either, since these medications would reach toxic concentrations in the body before reaching effective concentrations in the brain. To address this problem, researchers at UCSF and elsewhere have been developing a procedure called convection-enhanced delivery (CED). CED is an experimental technique for directly infusing drugs into a brain tumor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657605/
The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment.Author: Waldemar Debinski, Stephen B Tatter
https://www.medscape.com/viewarticle/712531
Nov 06, 2019 · The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has …
https://www.unicare.com/dam/medpolicies/unicare/active/policies/mp_pw_a053521.html
Dec 18, 2019 · Convection-enhanced delivery of therapeutic agents into the brain is considered investigational and not medically necessary. Rationale Standard methods of delivering drugs to the brain by intravenous infusions of systemic drugs resulted in limited penetration of the central nervous system.
https://link.springer.com/article/10.1007/s13311-017-0520-4
Mar 15, 2017 · Convection-enhanced delivery (CED) is a promising technique that generates a pressure gradient at the tip of an infusion catheter to deliver therapeutics directly through the interstitial spaces of the central nervous system. It addresses and offers solutions to many limitations of conventional techniques, allowing for delivery past the blood–brain barrier in a targeted and safe manner that ...Author: A. M. Mehta, A. M. Sonabend, J. N. Bruce
http://www.aetna.com/cpb/medical/data/700_799/0731.html
Convection-enhanced delivery (CED) is a method of directly administering drugs into the brain in order to enhance the distribution of drugs throughout the brain parehcyma. It involves the stereotactic placement through cranial burr holes of several catheters into brain parenchyma and the subsequent infusion of antineoplastic agents or other ...
https://consultqd.clevelandclinic.org/the-cleveland-multiport-catheter-a-new-take-on-convection-enhanced-delivery-to-the-cns/
Oct 16, 2015 · The Cleveland Multiport Catheter: A New Take on Convection-Enhanced Delivery to the CNS. This novel CED device promises larger volume of drug distribution than with prior CED devices. Early human testing in glioma patients supports that hope, and use in …
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