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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508299/
Jun 13, 2015 · The development of colon-targeted oral drug delivery systems has gained increasing interest among formulation scientists in recent years. As discussed above, colon-specific drug delivery systems provide significant therapeutic benefits to the patients in terms of …Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · Colon Targeted Drug Delivery Systems: A Review on Primary and Novel Approaches. ... and the site-specificity of formulations can be poor.22 The decline in pH from the end of the small intestine to the colon can also result in ... Oral delayed release system for colonic specific drug delivery. Int J Pharm 1994; 108:77-83 .10.1016/0378-5173 ...Author: Anil K. Philip, Betty Philip
https://www.researchgate.net/publication/23656749_Modified-Release_Solid_Formulations_for_Colonic_Delivery
Modified-Release Solid Formulations for Colonic Delivery. ... (or delayed-release) system, time-controlled (or time-dependent) system, microbially-controlled system, and pressure-controlled system ...
https://www.capsugel.com/biopharmaceutical-technologies/colonic-delivery-technologies
Capsugel offers multiparticulate and capsule-coating technologies to achieve colonic drug delivery. This targeted delivery option has received increased attention not only for treatment of colon-specific diseases such as irritable bowel disease (IBD), but also to take advantage of the colon’s absorptive surface area and conditions to deliver specific drugs and treat specific indications.
https://www.researchgate.net/publication/244994822_Colon_targeted_drug_delivery_systems-A_review
Day by day there are new developments in field of colon specific drug delivery system. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the ...
https://patents.google.com/patent/EP0343993A1/en
Delayed release compositions comprising an active compound and glassy amylose are of use with a variety of different types of active compound but particularly for achieving the selective release of medicaments into the colon. ... EP0343993A1 - Delayed release formulations - Google Patents Delayed release formulations Download PDF InfoAuthor: Michael Charles Allwood, David Brian Archer, Stephen Gordon Ring
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1872-2113&volume=1&issue=1&spage=53
Keywords:Colonic delivery, colonic targeting, colonic delivery system, enteric-coating, delayed-release formulations, timecontrolled systems, coated dosage forms, osmotic-controlled systems, timed-release systems, colonic formulations. Abstract: Solid formulations intended for targeted drug release into the lower gastrointestinal (GI) tract are ...
https://www.sciencedirect.com/science/article/pii/S0939641118306210
This review focuses on oral CR formulations targeting the colon and colonic drug absorption, since the absorption in this segment of the gastrointestinal tract is of great relevance for oral CR formulations. 1.1. The colon as targeted absorption site. The colon is one of the sites where local and systemic delivery of drugs can take place.Author: Isabel Lozoya-Agullo, Isabel González-Álvarez, Matilde Merino-Sanjuán, Marival Bermejo, Marta Gonzál...
http://www.bioline.org.br/pdf?pr08028
multiparticulate drug delivery systems are especially suitable for achieving controlled or delayed release oral formulations with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time. The release of drug from microparticles
https://www.sciencedirect.com/science/article/pii/S0378517301009036
The optimum colonic drug delivery ZPG/tablet system provided the expected delayed-release sigmoidal patterns with a lag-time of 4.125–4.85 h and t 50% (the time for 50% of the drug to be released) at 7.45–8.70 h, depending on pectin/dextran ratio employed. The results also demonstrated that the untableted ZPG microparticles exhibited drug ...Author: Ibrahim El-Gibaly
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