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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · For colonic delivery, the prodrug is designed to undergo minimal hydrolysis in the upper tracts of GIT, and undergo enzymatic hydrolysis in the colon there by releasing the active drug moiety from the drug carrier.Author: Anil K. Philip, Betty Philip
https://www.capsugel.com/biopharmaceutical-technologies/colonic-delivery-technologies
One of the challenges to successful colonic delivery is the relatively small amount of water available for dissolution of dosage forms in the colon. The combination of reliable targeting technology and the delivery of drugs in a liquid dosage form can provide an optimal approach for colonic delivery.
https://www.sciencedirect.com/science/article/pii/S1740674905000260
Because the most common medical use of colonic drug delivery systems is the topical treatment of colonic inflammations (inflammatory bowel diseases (ibd)) [ 14 ], a more practical method adopted by the pharmaceutical industry was the use of enteric coating films (anionic polymers that resist the acidic pH of the stomach and ionize, swell and expose their load in the typical pH 6.8 of the small intestine) to …Author: Abraham Rubinstein
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508299/
Jun 13, 2015 · Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions.Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
http://ijpsr.com/bft-article/a-review-on-colon-targeted-drug-delivery-system/?view=fulltext
By definition, a colonic delivery refers to delivery of drugs accurately into the lower GI tract (by avoiding the drug release in upper GIT), which occurs primarily in the large intestine (i.e. colon) 2, 3, 4. Rectal administration is another route used for colon targeting, but it shows less compliance (uncomfortable) and becomes difficult to reach the colon.
https://www.ondrugdelivery.com/opportunities-innovations-colonic-drug-delivery/
Oral drug delivery to the colon has long been recognised to have several therapeutic advantages. Traditionally, targeting drugs to this region of the gastro-intestinal (GI) tract was viewed as a niche application, innately providing clinical benefits for localised diseases such as inflammatory bowel disease (IBD) or colorectal cancers.
http://www.jpsbr.org/index_htm_files/5.pdf
In the recent year colonic drug delivery has gained importance for delivery of drug for the treatment of local diseases associated with colon and systemic delivery of therapeutic peptides and proteins. Treatment could be more effective if it is possible for drug to be directly delivered to colon…
http://www.authorstream.com/Presentation/chinmayeechinni-1521280-colon-drug-delivery-system/
Aug 29, 2012 · INTRODUCTION Definition:-Colon drug delivery system refers to targeted delivery of drug in to the lower parts of GI tract , mainly large intestine. POTENTIAL APPLICATIONS OF CDDS: POTENTIAL APPLICATIONS OF CDDS Chronotherapy.
https://www.researchgate.net/publication/244994822_Colon_targeted_drug_delivery_systems-A_review
Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn's disease, ulcerative colitis, etc. but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs and anti-diabetic agents.
https://www.slideshare.net/GajananSanap/colon-targeted-drug-delivery-systems
Feb 27, 2016 · Azo polymeric new drug In which use of polymers as drug carriers for drug delivery to colon . Synthetic, naturally, sub-synthetic polymers used form colon targeted polymeric prodrug with azo linkage between polymer & drug moiety. The various azo …
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