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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · For colonic delivery, the prodrug is designed to undergo minimal hydrolysis in the upper tracts of GIT, and undergo enzymatic hydrolysis in the colon there by releasing the active drug moiety from the drug carrier.Author: Anil K. Philip, Betty Philip
https://www.capsugel.com/biopharmaceutical-technologies/colonic-delivery-technologies
One of the challenges to successful colonic delivery is the relatively small amount of water available for dissolution of dosage forms in the colon. The combination of reliable targeting technology and the delivery of drugs in a liquid dosage form can provide an optimal approach for colonic delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508299/
Jun 13, 2015 · Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of local diseases such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions.Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
https://link.springer.com/chapter/10.1007%2F978-0-387-49785-3_19
The prod rugapproach to colonic delivery is currently used to treat inflammatory bowel diseases (IBD), in which active drugs are liberated by the action of bacterial enzymes such as azo-reductase, glucosidases, and glucronidases in the colon (Friend, 1992; Sinha and Kumria, 2003).
https://www.researchgate.net/publication/226632655_Colonic_Delivery
Colonic delivery is more easily assessed in animals. A drug delivery index can be determined, based on drug in colonic tissue and in blood, under either single dose or steady-state conditions.
https://www.sciencedirect.com/science/article/pii/B9780081025536000258
Colonic delivery can be accomplished by oral or rectal administration. Suppositories and enemas are used for rectal delivery of drugs, but they are mainly used for the topical treatment of sigmoid and the descending colon [19], [20]. Hence oral delivery is the most preferred route for colon targeting of drugs.
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