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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853346/
Feb 12, 2007 · Therefore, coated microneedles are most suitable for potent drugs, such as therapeutic proteins, DNA and vaccines. Vaccine delivery using coated microneedles is especially attractive, because microneedle-based delivery to the skin can target dendritic cells residing in the epidermis for a more potent immune response.Author: Harvinder S. Gill, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/pii/S0168365906005839
Therefore, coated microneedles are most suitable for potent drugs, such as therapeutic proteins, DNA and vaccines. Vaccine delivery using coated microneedles is especially attractive, because microneedle-based delivery to the skin can target dendritic cells residing in …Author: Harvinder S. Gill, Mark R. Prausnitz
http://drugdelivery.chbe.gatech.edu/Papers/2007/Gill%20J%20Control%20Release%202007.pdf
Coated microneedles for transdermal delivery Harvinder S. Gilla, Mark R. Prausnitza,b,⁎ a Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA b School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA Received 7 August 2006; accepted 18 October 2006
https://www.sciencedirect.com/science/article/pii/S0168365917304881
2.6. Transdermal drug delivery in vitro. The coated polymer MNs (5 × 5 arrays, 650-μm height) were applied to the porcine cadaver skin (Pel-Freez, Rogers, AR) to evaluate the insertion and drug delivery efficiency in vitro, with IACUC approval using a house-made applicator.Before the test, the porcine cadaver skin was pretreated, including completely shaving, partly degreasing, and cleaning ...Author: Yang Chen, Bo Zhi Chen, Qi Lei Wang, Xuan Jin, Xin Dong Guo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588187/
Jun 29, 2015 · 2. Hollow Microneedles. Hollow microneedles (HM) can be fabricated from a commercially available 30 gauge hypodermic needles [].Pressure, and thereby flow rate, can be changed in HM for a rapid bolus injection, a slow infusion or a varied delivery rate [].HM can also be used to administer a larger dose of drug solution [].Verbaan et al. fabricated HM from 30G stainless steel needles [].Author: Kevin B. Ita
https://www.researchgate.net/publication/6631457_Coated_Microneedles_for_Transdermal_Delivery
Coated Microneedles for Transdermal Delivery Article in Journal of Controlled Release 117(2):227-37 · March 2007 with 130 Reads How we measure 'reads'
http://drugdelivery.chbe.gatech.edu/Papers/2007/Jiang%20IOVS%202007.pdf
Coated Microneedles for Drug Delivery to the Eye Jason Jiang,1,2 Harvinder S. Gill,3 Deepta Ghate,1 Bernard E. McCarey,1 Samir R. Patel,2 Henry F. Edelhauser,*,1 and Mark R. Prausnitz*,2,3 PURPOSE. To test the hypothesis that coated microneedles can deliver drugs into …
https://onlinelibrary.wiley.com/doi/full/10.1111/j.2042-7158.2011.01369.x
Microneedle application is an emerging technique for transdermal drug delivery and this is reflected by the large number of patent applications filed. 125-133 The majority of these patent applications are focused around design of, and delivery through, hollow microneedles since a higher amount of drug can be delivered from such microneedles as ...Author: Shital H. Bariya, Mukesh C. Gohel, Tejal A. Mehta, Om Prakash Sharma
https://www.aiche.org/conferences/aiche-annual-meeting/2006/proceeding/paper/543e-coated-microneedles-transdermal-drug-delivery
The release kinetics of the coatings in aqueous solution or skin in vitro was found to be 20 seconds, indicating that the coated microneedles can be used for fast delivery of drugs. Imaging the delivery profile of drug from coated microneedles into porcine or human skin was done using histology.
http://europepmc.org/article/MED/17169459
Oct 24, 2006 · Coated microneedles for transdermal delivery. Gill HS 1, Prausnitz MR. Author information. Affiliations. 1 author. 1. Wallace H Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, Atlanta, GA 30332-0100, USA. ...Author: Harvinder S. Gill, Mark R. Prausnitz
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