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https://www.ncbi.nlm.nih.gov/pubmed/17724185
PURPOSE: To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner. METHODS: Solid metal microneedles measuring 500 to 750 microm in length were coated with model drugs, protein, and DNA; inserted into nonpreserved human cadaveric sclera; and imaged.Author: Jason Jiang, Harvinder S. Gill, Deepta Ghate, Bernard E. McCarey, Samir R. Patel, Henry F. Edelhause...
https://iovs.arvojournals.org/article.aspx?articleid=2125529
To determine whether coated microneedles can deliver a model drug into the eye in vivo, single microneedles coated with 0.28 μg of sodium fluorescein were inserted into the cornea of an anesthetized rabbit.Author: Jason Jiang, Harvinder S. Gill, Deepta Ghate, Bernard E. McCarey, Samir R. Patel, Henry F. Edelhause...
http://drugdelivery.chbe.gatech.edu/Papers/2007/Jiang%20IOVS%202007.pdf
To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner. METHODS. Solid metal microneedles measuring 500 to 750 m in length were coated with model drugs, protein, and DNA; inserted into nonpreserved human cadaveric sclera; and im-aged.
https://www.researchgate.net/publication/6116499_Coated_Microneedles_for_Drug_Delivery_to_the_Eye
To test the hypothesis that coated microneedles can deliver drugs into the eye via intrascleral and intracorneal routes in a minimally invasive manner. Solid metal microneedles measuring 500 to 750 microm in length were coated with model drugs, protein, and DNA; inserted into nonpreserved human cadaveric sclera; and imaged.
https://arstechnica.com/science/2018/11/dissolving-microneedles-could-replace-injections-for-chronic-eye-disease/
The microneedles get the drug into the eye, but they release it quickly, and the natural circulation of fluid in the eye clears away most of the drug before it can be absorbed; it’s the same...
https://www.academia.edu/10307211/Coated_Microneedles_for_Drug_Delivery_to_the_Eye
Coated Microneedles for Drug Delivery to the Eye
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419303/
In addition to applications in the skin, microneedles have also been used for drug delivery to the eye. In the first study of ocular drug delivery, coated microneedles were used to administer model compounds into the sclera and corneal stroma . Administration of pilocarpine to the corneal stroma in this way achieved a bioavailablity almost two orders of magnitude greater than topical delivery and induced significant and extended constriction of the pupil in the rabbit eye.Author: Yeu-Chun Kim, Yeu-Chun Kim, Yeu-Chun Kim, Jung-Hwan Park, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853346/
Feb 12, 2007 · Therefore, coated microneedles are most suitable for potent drugs, such as therapeutic proteins, DNA and vaccines. Vaccine delivery using coated microneedles is especially attractive, because microneedle-based delivery to the skin can target dendritic cells residing in the epidermis for a more potent immune response.Author: Harvinder S. Gill, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231993/
More recently, microneedles have been studied for applications in the eye. 27 In a first study, solid microneedles coated with pilocarpine were applied to the cornea and shown to dramatically increase bioavailability of the drug in the anterior segment compared with topical eye drops as evidenced by pupil dilation in rabbits. 28 Additional studies have addressed posterior segment delivery using solid and hollow microneedles for drug delivery …Author: Yoo C. Kim, Hans E. Grossniklaus, Henry F. Edelhauser, Mark R. Prausnitz
https://www.researchgate.net/publication/23446611_Intrascleral_Drug_Delivery_to_the_Eye_Using_Hollow_Microneedles
Intrascleral Drug Delivery to the Eye Using Hollow Microneedles. This study tested the hypothesis that hollow microneedles can infuse solutions containing soluble molecules, nanoparticles, and microparticles into sclera in a minimally invasive manner.
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