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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853346/
Feb 12, 2007 · To further quantify the delivery efficiency of coated microneedles, rows of microneedles coated with vitamin B were inserted into pig cadaver skin. A total mass of 7.86 ± 0.3 μg of vitamin B was originally coated on these microneedles. After a 5-min insertion of these microneedles …Author: Harvinder S. Gill, Mark R. Prausnitz
https://www.sciencedirect.com/science/article/pii/S0168365906005839
In vitro dissolution time and delivery efficiency. Single microneedles (n = 3) coated with vitamin B, calcein or sulforhodamine were inserted into porcine cadaver skin for 10 s or 20 s. Upon removal, these microneedles were imaged by fluorescence microscopy to check for presence of residual coating.Author: Harvinder S. Gill, Mark R. Prausnitz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695830/
Nov 05, 2015 · Here, the molten dip coating process was used to develop uniform lidocaine coated MNs for transdermal delivery. Polyethylene glycol (PEG) was used as a hydrophilic matrix with a lidocaine base to create the solid dispersion. Drug stability was achieved even at …Author: Rita Haj-Ahmad, Hashim Khan, Muhammad Sohail Arshad, Muhammad Sohail Arshad, Manoochehr Rasekh, Amja...
http://europepmc.org/theses/ETH/2842
In the first strategy, coated microneedles (sharp-tipped, micron-sized structures) were developed to enable delivery of drugs directly into the skin by bypassing the stratum corneum barrier. In the second strategy, instead of bypassing the barrier, microdermabrasion was used to selectively abrade stratum corneum with sharp microparticles for topical drug application.Author: Harvinder Singh Gill
https://core.ac.uk/display/4714368
In the first strategy, coated microneedles (sharp-tipped, micron-sized structures) were developed to enable delivery of drugs directly into the skin by bypassing the stratum corneum barrier. In the second strategy, instead of bypassing the barrier, microdermabrasion was used to selectively abrade stratum corneum with sharp microparticles for topical drug application.Author: Harvinder Singh Gill
http://drugdelivery.chbe.gatech.edu/Papers/2007/Gill%20J%20Control%20Release%202007.pdf
Among these approaches, coated microneedles are attractive for rapid bolus delivery of high molecular weight molecules into the skin, and can be implemented as a simple ‘Band-Aid’-like system for self-administration. Further, storing drugs in a solid phase as a coating on microneedles may enhance their long-term stability, even at room temperature.
https://www.mdpi.com/1999-4923/7/4/486/pdf
in personalized drug delivery via controlled deposition onto MN templates. Keywords: microneedles; coatings; drug delivery; coating process; films; particles 1. Introduction Transdermal drug delivery (e.g., transdermal patches) offers an attractive alternative to oral and parenteral routes of drug administration.Author: Rita Haj-Ahmad, Hashim Khan, Muhammad Sohail Arshad, Muhammad Sohail Arshad, Manoochehr Rasekh, Amja...
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