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https://www.neuway-pharma.com/cns-drug-delivery/
The target of NEUWAY´s CNS Drug Delivery Technology is to facilitate the transport of active drug substances through the blood-brain barrier (BBB). The BBB is an epithelium layer surrounding 600 kilometres cranial blood vessels. This layer controls the transport to and from the central nervous system (CNS) and protects our brain from toxins and pathogens.
https://www.medlink.com/article/drug_delivery_to_the_central_nervous_system
The delivery of drugs to the brain is a challenge in the treatment of CNS disorders. The major obstruction to CNS drug delivery is the blood-brain barrier, which limits the access of drugs to the brain substance. In the past, treatment of CNS disease was done mostly with systemically administered drugs. This trend continues.
https://www.renishaw.com/en/lab2clinic-central-nervous-system-cns-drug-delivery-service--44803
Lab2Clinic CNS drug delivery service is an innovative concept which leverages Renishaw's extensive experience in neurological drug delivery to accelerate the drug development timeline, aiding translation from research to clinical trials.
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
Blood-Brain Barrier and CNS Drug Delivery Parvin Zakeri-Milani , Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran. The central nervous system is protected by barriers which control the passage of various chemical substances and microscopic objects, thereby regulating brain homeostasis.
https://www.hindawi.com/journals/bmri/2014/869269/
Present review highlights various drug delivery systems used for delivery of pharmaceutical agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic substances through the endothelial capillaries (BBB) for CNS therapeutics. In addition, the use of ultrasound in delivery of therapeutic agents/biomolecules such as proline rich peptides, prodrugs ...Author: Ravi Kant Upadhyay
http://www.authorstream.com/Presentation/amol.sabale-1380346-brain-targeted-drug-delivery-system/
Apr 05, 2012 · CELLULAR BARRIERS TO DRUG DELIVERY TO CNS: The first and largest interface is the brain capillary endothelial cells that form the Blood brain barrier ( BBB). The second barrier is the Blood–cerebrospinal fluid barrier (BCSFB) .
https://www.slideshare.net/ANUSHANADIKATLA/drug-delivery-to-the-brain-124040723
Nov 26, 2018 · Polymeric micelles have been utilized for delivery of CNS drugs across the BBB, and for oral delivery of drugs and tumour-specific delivery of antineoplastic agents. Examples: • pluronic P85 micelles loaded with a neuroleptic drug were targeted to the brain by conjugating micelles with neurospecific antibodies, or using insulin as targeting moieties.
https://www.researchgate.net/publication/23796829_CNS_Drug_Delivery_Systems_Novel_Approaches
Transport of drugs from circulating blood into the central nervous system (CNS) is restricted by the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier, which are formed by ...
https://sites.ualberta.ca/~csps/JPPS6(2)/A.Misra/delivery.pdf
combined. The major problem in drug delivery to brain is the presence of the BBB. Drugs that are effective against diseases in the CNS and reach the brain via the blood compartment must pass the BBB. In order to develop drugs which penetrate the BBB well to exhibit the expected CNS therapeutic effects, it is of great importance
https://www.slideshare.net/ShashankSoni/brain-targeted-drug-delivery
Mar 23, 2017 · Advantages of using nanoparticles for CNS targeted drug delivery protect drugs against chemical and enzymatic degradation. small size --- penetrate into even small capillaries ---taken up within cells ----drug accumulate at the targeted sites The use of biodegradable materials ---allows sustained drug release at the targeted site after injection Limitations of using nanoparticles for CNS targeted drug delivery …
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