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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751425/
Feb 24, 2006 · CNS drug delivery: Opioid peptides and the blood-brain barrier Ken A. Witt and Thomas P. Davis Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University, Edwardsville, 200 University Park Drive, 62026 Edwardsville, IL.Author: Ken A. Witt, Thomas P. Davis
https://link.springer.com/article/10.1208%2Faapsj080109
Mar 01, 2006 · Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated potency of peptides and the centrally mediated actions of pain processes. Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain.Author: Ken A. Witt, Thomas P. Davis
https://link.springer.com/chapter/10.1007/978-0-387-76678-2_30
The various modes of modification of therapeutic peptides may be amalgamated, creating more efficacious “hybrid” peptides, with synergistic delivery to the CNS. The ongoing development of these strategies provides promise that peptide drugs may be useful for the treatment of pain and other neurologically-based disease states in the future.Author: Ken A. Witt, Thomas P. Davis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127280/
Jul 20, 2014 · Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier ... But delivery of peptides and proteins seems to be very hard to send them for ... Wu D, Sakane T. Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain up take of brain-derived neurotrophic factor ...Author: Ravi Kant Upadhyay
https://www.researchgate.net/publication/7196131_CNS_Drug_Delivery_Opioid_Peptides_and_the_Blood-Brain_Barrier
CNS Drug Delivery: Opioid Peptides and the Blood-Brain Barrier. ... Role of the Blood-Brain Barrier in CNS Drug Delivery . The brain is one of the least accessible or gans for the deliv-
https://arizona.pure.elsevier.com/en/publications/cns-drug-delivery-opioid-peptides-and-the-blood-brain-barrier-2
title = "CNS drug delivery: Opioid peptides and the blood-brain barrier", abstract = "Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions.Author: Ken A. Witt, Thomas P. Davis
https://arizona.pure.elsevier.com/en/publications/cns-drug-delivery-opioid-peptides-and-the-blood-brain-barrier
Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain. Reasons for the limited use are primarily based in the physiochemical and biochemical nature of peptides. Numerous approaches have been devised in an attempt to improve peptide drug delivery to the brain, with variable results.Author: Ken A. Witt, Thomas P. Davis
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