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https://www.medlink.com/article/drug_delivery_to_the_central_nervous_system
The delivery of drugs to the brain is a challenge in the treatment of CNS disorders. The major obstruction to CNS drug delivery is the blood-brain barrier, which limits the access of drugs to the brain substance. This article describes various strategies to facilitate drug delivery …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026551/
May 10, 2014 · Considering special cellular structures of protective barriers, CNS drug discovery has to merge drug design or modification with the development of efficient delivery systems. Drug access directly into the brain has been extensively investigated during the last decade and has made marked progress recently.Author: Cui-Tao Lu, Ying-Zheng Zhao, Ho Lun Wong, Jun Cai, Lei Peng, Xin-Qiao Tian
https://www.marketwatch.com/press-release/drug-delivery-in-central-nervous-system-cns-diseases-2019-technologies-markets-companies---forecast-to-2028---researchandmarketscom-2019-02-04
Feb 04, 2019 · The delivery of drugs to central nervous system (CNS) is a challenge in the treatment of neurological disorders. Drugs may be administered directly into the CNS or …
https://www.neuway-pharma.com/cns-drug-delivery/
CNS Drug Delivery Technology. The target of NEUWAY´s CNS Drug Delivery Technology is to facilitate the transport of active drug substances through the blood-brain barrier (BBB). The BBB is an epithelium layer surrounding 600 kilometres cranial blood vessels.
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
Physiological On the other hand, receptor-mediated transport pathways are also available for CNS drug delivery. There are several transport systems for nutrients and endogenous compounds in brain endothelial cells including receptors such as transferrin, folate, Interleukin-13 a2, Insulin, Low Density Lipoprotein (LDL), Glutamate, etc.
https://www.renishaw.com/en/lab2clinic-central-nervous-system-cns-drug-delivery-service--44803
Lab2Clinic CNS drug delivery service is an innovative concept which leverages Renishaw's extensive experience in neurological drug delivery to accelerate the drug development timeline, aiding translation from research to clinical trials.
https://drug-dev.com/cns-delivery-bypassing-the-bbb-drug-delivery-from-the-olfactory-mucosa-to-the-cns/
Intranasal olfactory mucosal administration of therapeutic agents for the treatment of neurodegenerative and many CNS diseases overcomes the limitations due to the BBB, and provides an effective direct delivery method for a selective group of therapeutic agents to treat the brain regions that are pathologically affected with Alzheimer’s and Parkinson’s disease as well as other CNS diseases.
https://www.researchgate.net/publication/23796829_CNS_Drug_Delivery_Systems_Novel_Approaches
CNS Drug Delivery Systems: Novel Approaches. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127280/
Jul 20, 2014 · However, transport of therapeutic peptides through BBB remains a challenge for peptide drug delivery into the central nervous system (CNS) (Table 1). However, chimeric peptides carry the drug into the brain to targeted sites though it does not transport through the BBB. For this purpose drug is conjugated to a brain drug-targeting vector . These chimeric proteins easily pass through BBB and presence of these peptide drugs …Author: Ravi Kant Upadhyay
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · The complexity of the BBB complicates CNS drug delivery, but also provides many unique opportunities for drug delivery. Manipulation of transporters, secretory functions, the extracellular pathways, and adsorptive transcytosis are examples of promising approaches to drug development.Author: William A. Banks
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