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https://www.medlink.com/article/drug_delivery_to_the_central_nervous_system
Overview. The delivery of drugs to the brain is a challenge in the treatment of CNS disorders. The major obstruction to CNS drug delivery is the blood-brain barrier, which limits the access of drugs to the brain substance.This article describes various strategies to facilitate drug …
https://www.renishaw.com/en/lab2clinic-central-nervous-system-cns-drug-delivery-service--44803
Lab2Clinic™ CNS drug delivery service is an innovative concept which leverages Renishaw’s extensive experience in neurological drug delivery to accelerate the drug development timeline, aiding translation from research to clinical trials.
https://www.researchgate.net/publication/23796829_CNS_Drug_Delivery_Systems_Novel_Approaches
CNS Drug Delivery Systems: Novel Approaches. ... patients suffering from fatal and/or debilitating central nervous system (CNS) diseases, such as brain tumours, HIV encephalopathy, epilepsy ...
https://www.hindawi.com/journals/bmri/2014/869269/
Present review highlights various drug delivery systems used for delivery of pharmaceutical agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic substances through the endothelial capillaries (BBB) for CNS therapeutics. In addition, the use of ultrasound in delivery of therapeutic agents/biomolecules such as proline rich peptides, prodrugs ...Author: Ravi Kant Upadhyay
https://www.neuway-pharma.com/cns-drug-delivery/
Description of the CNS Drug Delivery TechnologyThe target of NEUWAY´s CNS Drug Delivery Technology is to facilitate the transport of active drug substances through the blood-brain barrier (BBB). The BBB is an epithelium layer surrounding 600 kilometres cranial blood vessels.
https://drug-dev.com/cns-delivery-bypassing-the-bbb-drug-delivery-from-the-olfactory-mucosa-to-the-cns/
CNS DELIVERY – Bypassing the BBB: Drug Delivery From the Olfactory Mucosa to the CNS. INTRODUCTION. As therapeutic agents have evolved to treat central nervous system (CNS) afflictions, the blood brain barrier (BBB) has prevented the use of many of these drugs for treating neurodegenerative diseases, such as Alzheimer’s, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026551/
May 10, 2014 · Introduction. Systemic drug treatment of neurological diseases, such as brain tumors, inborn metabolic errors (eg, lysosomal storage diseases), and infectious and neurodegenerative diseases, is a daunting challenge due to the unique protective barriers of the central nervous system (CNS).1,2 Such innate barriers, mainly the blood–brain barrier (BBB) and the blood–cerebrospinal …Author: Cui-Tao Lu, Ying-Zheng Zhao, Ho Lun Wong, Jun Cai, Lei Peng, Xin-Qiao Tian
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127280/
Jul 20, 2014 · However, transport of therapeutic peptides through BBB remains a challenge for peptide drug delivery into the central nervous system (CNS) (Table 1). However, chimeric peptides carry the drug into the brain to targeted sites though it does not transport through the BBB. For this purpose drug is conjugated to a brain drug-targeting vector ...Author: Ravi Kant Upadhyay
https://www.journals.elsevier.com/journal-of-controlled-release/news/jcr-topic-collection-central-nervous-system/
3. Systemic delivery For CNS drug delivery, particularly, colloidal drug nanocarriers (i.e., micelles, liposomes, and nanoparticles) could allow non-transportable drugs to cross the BBB by masking their intrinsic physicochemical characteristics through encapsulation of them inside nanocarriers.
https://www.sciencedirect.com/book/9780128139974/nervous-system-drug-delivery
Drug delivery to the central nervous system (CNS) after stroke aims to prevent neuronal damage by mitigating primary and secondary brain injury, and by promoting angiogenesis, neurogenesis, and synaptogenesis. Stroke treatment strategies include early revascularization through delivery of thrombolytics to recanalize intracranial vessels and ...
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