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https://www.sciencedirect.com/science/article/pii/S0168365913009681
Chitosan nanoparticles for siRNA delivery: Optimizing formulation to increase stability and efficiency. ... All of these barriers need to be taken into account to develop powerful siRNA delivery systems. Chitosan is one of the most commonly studied polymers in non-viral gene therapy.Author: Héloïse Ragelle, Raphaël Riva, G. Vandermeulen, B. Naeye, Vincent Pourcelle, C. S. Le Duff, C. D'Hae...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680562/
Jul 15, 2019 · Chitosan for siRNA Delivery. Chitosan is a biopolymer derived from the deacetylation of chitin, which can be extracted from the exoskeleton of crustaceans (crabs, shrimp, krill, etc.), insects, and from cell walls of fungi .Author: Inés Serrano-Sevilla, Álvaro Artiga, Scott G. Mitchell, Laura De Matteis, Jesús M. de la Fuente
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250949/
Dec 01, 2014 · Chitosan nanoparticles were prepared using ultrasonication methodology at specific amplitudes and times of sonication. Subsequently, small interfering RNA (siRNA) was added to the solution at predetermined values of nitrogen to phosphorous ratio (N/P), and stirring time.Author: Elina Esmaeilzadeh Gharehdaghi, Amir Amani, Mohammad Reza Khoshayand, Mehdi Banan, Elika Esmaeilzade...
https://www.sciencedirect.com/science/article/pii/S1549963420300332
However, siRNA instability and inefficient delivery are the main hindrances. To address this issue, we developed a nano-sized siRNA loaded therapeutic delivery system. The chitosan-hyaluronic acid nano-polyplexes were prepared by the modified ionic gelation method.Author: Farkhondeh Chaharband, Narsis Daftarian, Mozhgan Rezaei Kanavi, Reyhaneh Varshochian, Maliheh Hajira...
https://pubs.acs.org/doi/10.1021/nn300106t
Composite nanofibers of biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning. Acidic/alkaline hydrolysis and a bulk/surface degradation mechanism were investigated in order to achieve an optimized release profile for prolonged and efficient gene silencing.Author: Menglin Chen, Shan Gao, Mingdong Dong, Jie Song, Chuanxu Yang, Kenneth Alan Howard, Jørgen Kjems, Fl...
https://www.researchgate.net/publication/280266171_Chitosan_and_its_derivatives_as_nanocarriers_for_siRNA_delivery
Chitosan and its derivatives as nanocarriers for siRNA delivery Article in Journal of Drug Delivery Science and Technology 22(1):29-42 · December 2012 with 54 Reads How we measure 'reads'
https://pubs.acs.org/doi/10.1021/acs.biomac.7b01297
Chitosan (CS) shows in vitro and in vivo efficacy for siRNA delivery but with contradictory findings for incompletely characterized systems. For understanding which parameters produce effective delivery, a library of precisely characterized chitosans was produced at different degrees of deacetylation (DDAs) and average molecular weights (Mn).Author: Mohamad Gabriel Alameh, Marc Lavertu, Nicolas Tran-Khanh, Chi-Yuan Chang, Frédéric Lesage, Martine B...
https://www.hindawi.com/journals/jphar/2013/812387/
The current study utilizes a peptide (TAT and MGF) tagged PEGylated chitosan nanoparticle formulation for siRNA delivery, administered intranasally, which can bypass the blood brain barrier. The study investigates the optimal dose, duration, biodistribution, and toxicity, of the nanoparticle-siRNA formulation, in-vivo.Author: Meenakshi Malhotra, Catherine Tomaro-Duchesneau, Shyamali Saha, Satya Prakash
https://www.hindawi.com/journals/ijbm/2013/146320/
Chitosan nanoparticles (CS NPs) exhibit good physicochemical properties as drug delivery systems. The aim of this study is to determine the modulation of preparative parameters on the physical characteristics and colloidal stability of CS NPs. CS NPs were fabricated by ionic interaction with dextran sulphate (DS) prior to determination of their storage stability. The smallest CS NPs of <svg ...Author: Haliza Katas, Maria Abdul Ghafoor Raja, Kai Leong Lam
https://www.researchgate.net/publication/51985258_Oligoarginine-modified_chitosan_for_siRNA_delivery
Chitosan-TPP nanoparticles with entrapped siRNA are shown to be better vectors as siRNA delivery vehicles compared to chitosan-siRNA complexes possibly due to their high binding capacity and ...
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