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https://www.ingentaconnect.com/content/asp/jnd/2013/00000001/00000002/art00008
Jun 02, 2013 · Home / Journal of Nanopharmaceutics and Drug Delivery, Volume 1, Number 2 Chitosan Self-Aggregates and Micelles in Drug Delivery Buy Article: $106.38 + tax (Refund Policy) Source: Journal of Nanopharmaceutics and Drug Delivery, Volume 1, Number 2 ...
https://pubs.acs.org/doi/10.1021/mp050010c
Chitosan-based polymer micelles have a splendid outlook for drug delivery owing to the interesting properties, abundance, and low cost of chitosan. A new method of preparation of water-soluble N-palmitoyl chitosan (PLCS) which can form micelles in water is developed in this paper.Author: Gang-Biao Jiang, Daping Quan, Kairong Liao, Haihua Wang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834947/
Due to the muco/bioadhesive nature of chitosan (Section 2.4), chitosan-based micelles have been used extensively to improve the oral drug delivery. Evaluated by a Caco-2 cell monolayer, chitosan-based micelles were demonstrated to inhibit the activity of P-glycoprotein 1 (P-gp) ATPase, which, consequently, can inhibit drug efflux and enhance ...Author: Nan Zhang, Patricia R. Wardwell, Rebecca A. Bader
https://www.sciencedirect.com/science/article/pii/B9781907568459000032
This modified chitosan also self-aggregates with plasmid DNA and allows efficient transfection of a simian kidney cell line (COS-1), thus showing the potential for gene delivery (Kim et al., 2001, Lee et al., 1998). The size and the structure of self-aggregated deoxycholic acid-modified chitosan are influenced by the molecular weight of ...
https://pubs.acs.org/doi/abs/10.1021/mp100289v
Dec 07, 2010 · Novel Polymer Micelles Prepared from Chitosan Grafted Hydrophobic Palmitoyl Groups for Drug Delivery Molecular Pharmaceutics. Jiang, Quan, Liao, and Wang Abstract: Chitosan-based polymer micelles have a splendid outlook for drug delivery owing to the interesting properties, abundance, and low cost of chitosan.Author: Hong Yuan, Lin-Juan Lu, Yong-Zhong Du, Fu-Qiang Hu
https://www.sciencedirect.com/science/article/abs/pii/S0939641112001038
In contrast to all other polysaccharides having a monograph in a pharmacopeia, chitosan has a cationic character because of its primary amino groups. These primary amino groups are responsible for properties such as controlled drug release, mucoadhesion, in situ gellation, transfection, permeation enhancement, and efflux pump inhibitory properties.Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
https://www.sciencedirect.com/topics/chemistry/micellar-drug
Circulating micelles protect the drug from metabolic degradation, so the plasma half-life is generally prolonged. Micelles are too large to cross ‘tight’ capillary endothelium, so transfer across the blood–brain barrier is not increased. They are able to cross …
https://www.researchgate.net/publication/259153726_Polysaccharide-Based_Micelles_for_Drug_Delivery
Due to the muco/bioadhesive nature of chitosan (Section 2.4), chitosan-based micelles have been used extensively to improve th e oral drug delivery . Evaluated by a Caco-2 cell monolayer,
https://www.sciencedirect.com/science/article/pii/S0939641112001038
Chitosan-based formulations used for ophthalmic drug delivery are hydrogels , nanoparticles , and coated colloidal systems . Chitosan-based systems have the potential for improving the retention and biodistribution of drugs applied topically onto the eye.Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
https://www.sciencedirect.com/topics/materials-science/micelle
Polymeric micelles have attracted much attention in drug delivery because of their ability to solubilize hydrophobic molecules, their small particle size, good thermodynamic solution stability, extended release of various drugs, and prevention of rapid clearance by the reticuloendothelial system (RES). Low critical micelle concentration (CMC), is another key characterization parameter for polymeric micelles.
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