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https://www.sciencedirect.com/science/article/abs/pii/S0169409X09003494
This review provides an overview of chitosan-based polymers for preparation of both therapeutic peptides/protein and antigen formulations. The physicochemical properties of these carrier systems as well as their applications in protein and antigen delivery through parenteral and mucosal (particularly nasal and pulmonary) administrations are summarized and discussed.Author: Maryam Amidi, Enrico Mastrobattista, Wim Jiskoot, Wim E. Hennink
https://www.researchgate.net/publication/38113381_Chitosan-based_delivery_systems_for_protein_therapeutics_and_antigens
Chitosan-based delivery systems enhance the absorption and/or cellular uptake of peptides/proteins across mucosal sites and have immunoadjuvant properties.
https://freepaper.me/downloads/abstract/10.1016/j.addr.2009.11.009
Chitosan-based delivery systems for protein therapeutics and antigens Therapeutic peptides/proteins and protein-based antigens are chemically and structurally labile compounds, which are almost exclusively administered by parenteral injections.
https://core.ac.uk/display/39734252
Therapeutic peptides/proteins and protein-based antigens are chemically and structurally labile compounds,\ud which are almost exclusively administered by parenteral injections. Recently, non-invasive mucosal routes\ud have attracted interest for administration of these biotherapeutics.
https://link.springer.com/chapter/10.1007/978-1-4614-9524-6_23
Feb 04, 2014 · ChiSys® has been used as a nasal vaccine delivery platform (in some instances combined with other adjuvants) for a number of different antigens, including diphtheria, seasonal influenza, avian influenza, anthrax, and Norwalk virus; both enhanced antibody responses and efficacy have been demonstrated.Author: Peter Watts, Alan Smith, Michael Hinchcliffe
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130252/
Mar 01, 2014 · Archimedes Development Ltd (Archimedes) has developed a novel delivery technology based on chitosan (ChiSys®), which has been shown to enhance the intranasal delivery of conventional drugs as well as peptides and proteins. 20, 21 This technology has shown promise for the nasal delivery of vaccine antigens, with the added benefit that chitosan displays positive adjuvant properties, …Author: Alan Smith, Michael Perelman, Michael Hinchcliffe
https://www.researchgate.net/publication/228070817_Chitosan-Based_Nanoparticles_as_Delivery_Systems_of_Therapeutic_Proteins
Chitosan-based delivery systems have been proposed as valid approaches to provide protective conditions to proteins from denaturation and loss of activity, during preparation and delivery, as well as during long-term storage of the prepared formulation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090273/
Apr 11, 2011 · TMC nanoparticles are a potential new delivery system for protein transport through the nasal mucosa.72 Wang et al,73 who prepared estradiol-loaded chitosan nanoparticles and investigated the levels of estradiol in blood and cerebrospinal fluid in rats after intranasal administration, showed that estradiol levels in the cerebrospinal fluid after intranasal administration were significantly higher than after intravenous administration.Author: Jun Jie Wang, Zhao Wu Zeng, Ren Zhong Xiao, Tian Xie, Guang Lin Zhou, Xiao Ri Zhan, Shu Ling Wang
https://link.springer.com/protocol/10.1007%2F978-1-61779-921-1_28
May 24, 2012 · Chitosan-based delivery systems have been proposed as valid approaches to provide protective conditions to proteins from denaturation and loss of activity, during preparation and delivery, as well as during long-term storage of the prepared formulation.Author: Pedro Fonte, José Carlos Andrade, Vítor Seabra, Bruno Sarmento
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