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https://www.sciencedirect.com/science/article/pii/S0169409X09002816
Chitosan-based formulations for the delivery of siRNA 4.1. Problems with siRNA delivery. In comparison to conventional DNA-based gene therapy,... 4.2. Chitosan molecular weight and concentration. 4.3. Degree of chitosan deacetylation. The …Author: Shirui Mao, Wei Sun, Thomas Kissel
https://www.sciencedirect.com/science/article/abs/pii/S0169409X09002816
In this paper, chitosan-based formulations for the delivery of DNA and siRNA were reviewed to facilitate the process of chitosan vector development for clinical application.Author: Shirui Mao, Wei Sun, Thomas Kissel
https://www.ncbi.nlm.nih.gov/pubmed/19796660
Jan 31, 2010 · In this paper, chitosan-based formulations for the delivery of DNA and siRNA were reviewed to facilitate the process of chitosan vector development for clinical application.Author: Shirui Mao, Wei Sun, Thomas Kissel
https://www.researchgate.net/publication/26863056_Chitosan-based_formulations_for_delivery_of_DNA_and_siRNA
Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro and in vivo for DNA and siRNA delivery systems because of their cationic charge, biodegradability and biocompatibility, as well as their mucoadhesive and permeability-enhancing properties.
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/62/issue/1
Chitosan-based nanostructures: A delivery platform for ocular therapeutics Maria de la Fuente, Manuela Raviña, Patrizia Paolicelli, Alejandro Sanchez, ... Maria Jose Alonso
http://xueshu.baidu.com/usercenter/paper/show?paperid=3e403952f28ebae5ac08845dcf0fe91c&site=xueshu_se
Chitosan-based formulations for delivery of DNA and siRNA ... In this paper, chitosan-based formulations for the delivery of DNA and siRNA were reviewed to facilitate the process of chitosan vector development for clinical application. In addition to formulation optimization, chitosan structure modification or additive incorporation is an ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627531/
Jun 25, 2019 · Especially for cationic chitosan-based formulations, polyanions in the blood (such as serum proteins and glycosaminoglycans) can compete with siRNA/DNA for binding, resulting in the unpacking of the chitosan-based complexes and lead to premature siRNA/DNA release before reaching the intended site [60,61,62].Author: Ye Cao, Yang Fei Tan, Yee Shan Wong, Melvin Wen Jie Liew, Subbu Venkatraman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250949/
Dec 01, 2014 · Chitosan nanoparticles were prepared using ultrasonication methodology at specific amplitudes and times of sonication. Subsequently, small interfering RNA (siRNA) was added to the solution at predetermined values of nitrogen to phosphorous ratio (N/P), and stirring time.Author: Elina Esmaeilzadeh Gharehdaghi, Amir Amani, Mohammad Reza Khoshayand, Mehdi Banan, Elika Esmaeilzade...
https://www.sciencedirect.com/science/article/pii/S0168365913009681
The developed formulations of PEGylated chitosan-based nanoparticles that achieve high gene silencing in vitro, low cytotoxicity and high stability in plasma could be promising for intravenous delivery of siRNA.Author: Héloïse Ragelle, Raphaël Riva, G. Vandermeulen, B. Naeye, Vincent Pourcelle, C. S. Le Duff, C. D'Hae...
https://www.sciencedirect.com/science/article/pii/S0939641112001038
Chitosan-based formulations used for ophthalmic drug delivery are hydrogels [43], nanoparticles [44], and coated colloidal systems [45]. Chitosan-based systems have the potential for improving the retention and biodistribution of drugs applied topically onto the …Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
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