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https://www.sciencedirect.com/science/article/pii/S0168365903001263
Apr 29, 2003 · Chitosan, a natural polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for the development of conventional and novel gastrointestinal (GI) drug and gene delivery systems.Author: Radi Hejazi, Mansoor Amiji
https://www.ncbi.nlm.nih.gov/pubmed/12711440
Apr 29, 2003 · Chitosan, a natural polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for the development of conventional and novel gastrointestinal (GI) drug and gene delivery systems.Author: Radi Hejazi, Mansoor Amiji
https://www.researchgate.net/publication/10791217_Chitosan-based_gastrointestinal_delivery_systems
Chitosan-based gastrointestinal delivery systems. Chitosan, a natural polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. These properties make chitosan a good candidate for the development of conventional and novel gastrointestinal (GI) drug and gene delivery systems.
https://www.researchgate.net/publication/224914485_Chitosan-based_drug_delivery_systems
chitosan-based colloidal systems were found to work as transmu- cosal drug carriers, either facilitating the transport of drugs to the inner eye or their accumulation into the corneal epithelia.
https://www.sciencedirect.com/science/article/pii/S0141813020315105
Chitosan nanocarriers can be serves as oral delivery systems, which protect drugs from the acidic environment and proteolytic deactivation in the stomach and overcome intestinal barriers such as the mucus layer, TJs of epithelial cells and intestinal proteolytic enzyme barriers.
https://www.sciencedirect.com/science/article/pii/S0939641112001038
Chitosan-based formulations used for ophthalmic drug delivery are hydrogels , nanoparticles , and coated colloidal systems . Chitosan-based systems have the potential for improving the retention and biodistribution of drugs applied topically onto the eye.Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
http://www.nephro-pathology.com/uploads/1/0/0/4/10044970/chitosan_mediated_targeted_drug_delivery.pdf
delivery to the colon. Chitosan-based delivery systems have been widely studied for colonic drug targeting since this system can protect therapeutic agents from the hostile conditions of the upper gastrointestinal tract and release the entrapped agents speci.cally at the …
https://www.researchgate.net/publication/283640914_Oral_insulin_delivery_systems_using_chitosan-based_formulation_A_review
In order to increase nanocarrier stability in the gastric environment recent delivery systems have been developed based on modified chitosan through conjugation, quaternization, thiolation,...
https://www.sciencedirect.com/science/article/pii/B9780128170557000042
Chitosan-based delivery of proteins and antigens In terms of its superior potencies, protein therapeutics and antigens have turned up as important agents in the therapy of an extensive spectrum of diseases, including metabolic disorders, cancer, and autoimmune diseases.Author: Yuefei Zhu, Yiyang Liu, Zhiqing Pang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508299/
Jun 13, 2015 · Formation of a pharmacologically active metabolite by the colonic metabolism of drugs is a commonly used “prodrug” approach for the colon-specific drug delivery systems . Formulation Factors The formulation factors that influence colonic drug delivery and bioavailability includes physicochemical properties of the drugs, the dose, and the dosage form factors.Author: Seth Amidon, Jack E. Brown, Vivek S. Dave
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