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https://www.tandfonline.com/doi/full/10.1080/10717540490280705
May 16, 2013 · Chitosan can be useful as a nonviral vector for gene delivery. Although there are several reports to form chitosan-pDNA particles, the optimization and effect on transfection remain insufficient. The chitosan-pDNA nanoparticles were formulated using complex coacervation and solvent evaporation techniques. The important parameters for the encapsulation efficiency were investigated, including ...Author: Asuman Bozkir, Ongun Mehmet Saka
https://www.sciencedirect.com/science/article/pii/S0378517398003780
Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNAAuthor: SimonC.W. Richardson, HannoV.J. Kolbe, Ruth Duncan
https://www.sciencedirect.com/science/article/pii/S0939641112001038
In addition, chitosan–DNA-based drug complexes protect at least to some extend towards degradation by DNAses in this way improving the bioavailability of DNA-based drugs delivered into the body . As the transfection efficiency of conventional chitosans is generally found to be low, the polysaccharide was modified following different strategies in order to improve its properties.Author: Andreas Bernkop-Schnürch, Sarah Dünnhaupt
https://sites.ualberta.ca/~csps/JPPS7(2)/K.Turan/chitosan.htm
Our in vitro transfection results showed that the cell type is an important limitation for DNA delivery with chitosan polymers. HEK293 cells were more efficiently transfected than HeLa and fibroblastic 3T3 cells. Chitosan-DNA microparticles prepared with 0.75% chitosan …
https://pubs.acs.org/doi/abs/10.1021/bc050228h
Chitosan is a useful nonviral vector for gene delivery. To make a pDNA/chitosan complex specific to hepatocytes, lactose-modified chitosan (lac-chitosan) was synthesized.Author: Mayu Hashimoto, Minoru Morimoto, Hiroyuki Saimoto, Yoshihiro Shigemasa, Toshinori Sato
https://www.tandfonline.com/doi/abs/10.1080/10717540490280705
Oct 07, 2008 · Chitosan can be useful as a nonviral vector for gene delivery. Although there are several reports to form chitosan-pDNA particles, the optimization and effect on transfection remain insufficient. The chitosan-pDNA nanoparticles were formulated using …Author: Asuman Bozkir, Ongun Mehmet Saka
https://link.springer.com/chapter/10.1007%2F978-3-662-47862-2_22
An efficient gene delivery system for cellular uptake of DNA is essential for gene therapy. Chitosan has been widely used as a promising non-viral carrier for gene delivery. It is a cationic polymer with free amino groups and can bind to anionic nucleic acids spontaneously.Author: Julide Akbuga, Suna Ozbas-Turan, Ceyda Ekentok
https://www.hindawi.com/journals/jnm/2014/246347/
In this work, several formulations of chitosan-DNA polyplexes incorporating hyaluronic acid were prepared and characterized for their gene transfection efficiency on both HEK293 and retinal pigment epithelial cells. The different polyplex formulations showed morphology, size, and charge compatible with a role in gene delivery.Author: Ana V. Oliveira, Diogo B. Bitoque, Gabriela A. Silva
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066342/
Dec 31, 2010 · Chitosan has been studied as nonviral gene delivery vector by forming a chitosan–DNA complex (polyplex) which was found to be efficient in transfection in vitro . As a coating material, chitosan has been used for surface modification and as a mucoadhesive enhancer in the form of biodegradable microspheres carrying peptides and proteins for mucosal and oral delivery ( 20 , 21 ).Author: Sunee Channarong, Wanpen Chaicumpa, Nuttanan Sinchaipanid, Ampol Mitrevej
https://www.hindawi.com/journals/jnm/2011/952060/
It is the intent of this study to synthesize cationic chitosan-PLGA NPs designed for pDNA delivery, to verify the physiochemical properties of the particles while exploring their effect on pDNA binding at varied ratios, and ultimately to identify the location of DNA relative to the particles in the pDNA-NP complex.Author: Hali Bordelon, Alexandru S. Biris, Cristina M. Sabliov, W. Todd Monroe
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