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https://rnaitherapeutics.blogspot.com/2009/09/is-dendrimer-sirna-delivery-reaching.html
Sep 30, 2009 · Is Dendrimer-siRNA Delivery Reaching Critical Mass? Dendrimers are branched, nanometer-sized, spherical modular structures that, depending on the monomers, surface and internal modifications, can be engineered to carry out various functions, including nucleic acid delivery.Author: Dirk Haussecker
https://rnaitherapeutics.blogspot.com/2009/09/
Sep 30, 2009 · Is Dendrimer-siRNA Delivery Reaching Critical Mass? Dendrimers are branched, nanometer-sized, spherical modular structures that, depending on the monomers, surface and internal modifications, can be engineered to carry out various functions, including nucleic acid delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816686/
The dendrimer-siRNA complex had a potent RNAi effect against the TTR gene expression, efficient endosomal escape and delivery of the siRNA complex to the cytoplasm with negligible cytotoxicity. After intravenous administration, The Lac-α-CDE/siRNA complex demonstrated a potent in …Author: Swati Biswas, Vladimir P. Torchilin
https://www.sciencedirect.com/science/article/pii/S1369702115002023
The use of nucleic acid constructs to treat or prevent certain types of disease is known as gene therapy. Gene therapy requires the introduction of foreign genes into targeted host cells to replace the mutated gene and/or initiate new functionalities .Gene delivery has progressed rapidly over the past two decades , .In addition to DNA-based gene therapy, RNA interference (RNAi) offers another ...Author: Prashant Kesharwani, Sanjeev Banerjee, Umesh Gupta, Mohd Cairul Iqbal Mohd Amin, Subhash Padhye, Faz...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289905/
Delivery of siRNA into cells remains a critical challenge. Our lab has shown a novel polyamidoamine (PAMAM) dendrimer with modified pentaerythritol derivative core (PD dendrimer) to exhibit high plasmid DNA transfection efficiency and low cytotoxicity. ...Author: Yue Zhang, Yue Zhang, Chenguang Zhou, Kwang Joo Kwak, Xinmei Wang, Bryant Yung, L. James Lee, Yanmin...
https://www.sciencedirect.com/science/article/pii/S0079670013000853
The expression dendrimer is derived from a Greek term dendron that means “tree”, which is logical in view of their typical structure with a number of branching units. Dendrimers are defined as synthetic macromolecules characterized by high branching points, three dimensional globular shape, monodispersity and nanometric size range.Author: Prashant Kesharwani, Keerti Jain, Narendra Kumar Jain
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