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https://www.inovio.com/technology/electroporation-delivery/electroporation-devices/intramuscular-delivery/
Inovio’s proprietary technology platforms are realizing the true promise and power of immunotherapy ... CELLECTRA ®: optimized delivery of SynCon ... Inovio has developed the CELLECTRA electroporation device to efficiently deliver DNA plasmids into cells where they can be expressed to generate robust antibody and T cell responses.
http://ir.inovio.com/news-and-media/news/press-release-details/2020/INOVIO-Receives-New-5-Million-Grant-to-Accelerate-Scale-Up-of-Smart-Delivery-Device-for-Its-COVID-19-Vaccine/default.aspx
Mar 12, 2020 · INOVIO Pharmaceuticals, Inc. (NASDAQ:INO) announced today that it has received a new $5 million grant from the Bill Melinda Gates Foundation to accelerate the testing and scale up of CELLECTRA® 3PSP proprietary smart device for the intradermal delivery of INO-4800, a DNA vaccine for COVID-19. INO-4800 is in preclinical studies and is planned to advance into Phase 1 clinical trials …
https://www.prnewswire.com/news-releases/inovios-cellectra-electroporation-delivery-technology-powers-durable-best-in-class-t-cell-responses-from-hiv-vaccine-in-human-study-214867291.html
Inovio's CELLECTRA® Electroporation Delivery Technology Powers Durable, Best-in-Class T-Cell Responses from HIV Vaccine in Human Study Next-generation HIV …
https://www.prnewswire.com/news-releases/inovio-receives-new-5-million-grant-to-accelerate-scale-up-of-smart-delivery-device-for-its-covid-19-vaccine-301022049.html
INOVIO Receives New $5 Million Grant to Accelerate Scale Up of Smart Delivery Device for Its COVID-19 Vaccine News provided by ... The next generation CELLECTRA 3PSP device is designed ...
http://ir.inovio.com/news-and-media/news/press-release-details/2013/Inovios-CELLECTRA-Electroporation-Delivery-Technology-Powers-Durable-Best-in-Class-T-Cell-Responses-from-HIV-Vaccine-in-Human-Study/default.aspx
Jul 10, 2013 · BLUE BELL, Pa., July 10, 2013 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE MKT: INO) announced today the peer-reviewed publication of results from two phase I trials (HVTN 070 and HVTN 080) of its PENNVAX ®-B preventive HIV DNA vaccine delivered with a DNA adjuvant and with or without Inovio's proprietary CELLECTRA ® electroporation delivery device.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109217/
Electroporation Enhanced DNA Vaccine Delivery. Electroporation (EP) is a method to introduce macromolecules such as nucleic acids into cells, either in vivo or in vitro, via the application of brief electric pulses to induce transient and reversible permeabilization of the cell membrane (Figure 1).Over the last decade the technique has evolved from an experimental technique to now being used ...Author: Niranjan Y Sardesai, David B Weiner
https://www.outsourcing-pharma.com/Article/2016/10/25/Inovio-s-DNA-vaccine-trial-on-hold-over-delivery-device-shelf-life-concerns
Delivery device The vaccine is administered by intramuscular injection. The Cellectra is a device applied to the injection site to encourage cells to take up the plasmids through a process called electroporation. Electroporation involves applying controlled, millisecond electrical pulses …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906411/
Oct 01, 2013 · Tolerability of intramuscular and intradermal delivery by CELLECTRA ® adaptive constant current electroporation device in healthy volunteers. ... Mean VAS score post-EP delivery with CELLECTRA ® device over time. Subject VAS score as reported on the day of EP. IM, intramuscular study, n = 10; ID, intradermal study, n = 10.Author: Malissa C Diehl, Jessica C Lee, Stephen E Daniels, Pablo Tebas, Amir S Khan, Mary Giffear, Niranjan ...
https://www.inovio.com/pipeline
INO-5401 is a highly optimized synthetic DNA immunotherapy and has the potential to be a foundational treatment in combination with checkpoint inhibitors. INO-5401 targets WT1, hTERT, and PSMA antigens. INO-5401 is delivered intramuscularly using the CELLECTRA® delivery device.
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