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https://www.sciencedirect.com/science/article/pii/B9780124160392000057
We have not observed measureable differences in siRNA delivery to cells in tissue culture with either isoform of the 9R peptide presumable because its primary function here is siRNA binding while cell-specific delivery is mediated by a distinct targeting molecule (Sang-Kyung Lee, Priti Kumar).Author: Sang-Kyung Lee, Sang-Kyung Lee, Alyssa Siefert, Jagadish Beloor, Tarek M. Fahmy, Priti Kumar
https://www.researchgate.net/publication/51972320_Cell-Specific_siRNA_Delivery_by_Peptides_and_Antibodies
Cell-Specific siRNA Delivery by Peptides and Antibodies Article · Literature Review in Methods in enzymology 502:91-122 · December 2012 with 194 Reads How we measure 'reads'
https://www.academia.edu/19157807/Cell-specific_siRNA_delivery_by_peptides_and_antibodies
Cellular targeting and intracellular delivery of small interfering RNA (siRNA) remain a critical barrier to the clinical application of RNA interference. This chapter provides an overview of various delivery agents employing protein ligands mediating
https://www.sciencedirect.com/science/article/pii/S0169409X16302368
Functional peptides for siRNA delivery ... The targeting ability of CPPs can be enhanced by linking them to a wide variety of ligands such as antibodies, aptamers, homing peptides, and small molecules. ... Y.H. Kim, S.W. Kim, M. Peipp, G.H. Fey, N. Manjunath, L.D. Shultz, S.K. Lee, P. ShankarT cell-specific siRNA delivery suppresses HIV-1 ...Author: Wanyi Tai, Xiaohu Gao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831028/
Sep 16, 2011 · The clinical application of siRNA is limited largely by the lack of efficient, cell-specific delivery systems. Antibodies are attractive delivery vehicles for targeted therapy due to their high specificity. In this study we describe the use of a humanized monoclonal antibody (mAb), hu3S193, against Lewis-Y (Le y), as a delivery vehicle for ...Author: Yuelong Ma, Claudia M. Kowolik, Piotr M. Swiderski, Marcin Kortylewski, Hua Yu, David A. Horne, Rich...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043559/
The use of chemically-synthesized short interfering RNAs (siRNAs) is the key method of choice to manipulate gene expression in mammalian cell cultures and in vivo.Several previous studies have aimed at inducing cell-specific RNA interference (RNAi) in order …Author: Sandra Koehn, Hendrik W Schaefer, Mirko Ludwig, Natja Haag, Ulrich S Schubert, Lydia Seyfarth, Diana...
https://www.cell.com/abstract/S0092-8674(08)00821-0
Aug 22, 2008 · Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the challenges of siRNA delivery and lack of suitable animal models. Using a delivery method for T cells, we show that siRNA treatment can dramatically suppress HIV infection. A CD7-specific single-chain antibody was conjugated to oligo-9-arginine peptide (scFvCD7-9R) for T cell-specific siRNA delivery in ...Author: Priti Kumar, Hong Seok Ban, Sang Soo Kim, Haoquan Wu, Todd Pearson, Dale L. Greiner, Amale Laouar, J...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(18)30023-4
Jun 01, 2018 · Gene therapy was performed for neuropathic pain by the knockdown of IRF5 using the MG1 peptide+siRNA-IRF5 complex (peptides, 3 μg; siRNA, 1 μg) and the comparative groups, which were MG2, AS1, and DRG complexes (peptides, 3 μg; siRNA, 1 μg) prepared with the same structure as the complex in Figure 6A. Because IRF5 is involved not in thermal ...Author: Tomoya Terashima, Nobuhiro Ogawa, Yuki Nakae, Toshiyuki Sato, Miwako Katagi, Junko Okano, Hiroshi Ma...
https://www.researchgate.net/publication/225046914_T_Cell-Specific_siRNA_Delivery_Using_Antibody-Conjugated_Chitosan_Nanoparticles
T Cell-Specific siRNA Delivery Using Antibody-Conjugated Chitosan Nanoparticles Article in Bioconjugate Chemistry 23(6) · May 2012 with 175 Reads How we measure 'reads'
https://www.alliedacademies.org/articles/cellspecific-rna-interference-by-peptideinhibitedpeptidaseactivated-sirnas.html
Peptide-inhibited-peptidase-activated siRNAs exhibit a new mechanistic alternative to obtain cell-specific activation of siRNA molecules in target cells (Figure 1). The challenge of this strategy is to find a target peptidase with cell-specific activity, which is able to activate the siRNAs by peptide cleavage.Author: Sandra Koehn, Hendrik W Schaefer, Mirko Ludwig, Natja Haag, Ulrich S Schubert, Lydia Seyfarth, Diana...
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