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https://www.nature.com/articles/nbt1223
Jun 25, 2006 · Technologies that mediate targeted delivery of small interfering RNAs (siRNAs) are needed to improve their therapeutic efficacy and safety. Therefore, we have developed aptamer-siRNA chimeric RNAs ...Author: James O McNamara, Eran R Andrechek, Yong Wang, Kristi D Viles, Rachel E Rempel, Eli Gilboa, Bruce A ...
https://www.ncbi.nlm.nih.gov/pubmed/16823371
Technologies that mediate targeted delivery of small interfering RNAs (siRNAs) are needed to improve their therapeutic efficacy and safety. Therefore, we have developed aptamer-siRNA chimeric RNAs capable of cell type-specific binding and delivery of functional siRNAs into cells.Author: James O McNamara, Eran R Andrechek, Yong Wang, Kristi D Viles, Rachel E Rempel, Eli Gilboa, Bruce A ...
http://ccc.chem.pitt.edu/wipf/Current%20Literature/Julia_2.pdf
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras Julia Vargas November 25th, 2006 Sullenger, B. A. et al Duke Center for Translational Research,
https://www.gene-quantification.de/mcnamara-sirna-2006.pdf
Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras James O McNamara II1,3, Eran R Andrechek2,3, Yong Wang1, Kristi D Viles1, Rachel E Rempel2, Eli Gilboa1, Bruce A Sullenger1 & Paloma H Giangrande1 Technologies that mediate targeted delivery of small interfering RNAs (siRNAs) are needed to improve their therapeutic efficacy
https://www.researchgate.net/publication/6962426_Cell_type-specific_delivery_of_siRNAs_with_aptamer-siRNA_chimeras
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. ... we have developed aptamer-siRNA chimeric RNAs capable of cell type-specific binding and delivery of functional siRNAs into ...
https://www.researchgate.net/publication/237683162_83_Cell-Type_Specific_Delivery_of_siRNAs_with_Aptamer-siRNA_Chimeras
Cell-Type Specific Delivery of siRNAs with Aptamer-siRNA Chimeras Article (PDF Available) in Molecular Therapy 13 · May 2006 with 107 Reads How we measure 'reads'
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(06)00358-3
This Journal Full Site. Advanced Search. Log in; RegisterAuthor: James O McNamara, Eran R Andrechek, Yong Wang, Kristi D Viles, Rachel E Rempel, Eli Gilboa, Bruce A ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)32284-5
Aug 01, 2008 · In this study, we demonstrate cell type–specific delivery of anti-human immunodeficiency virus (anti-HIV) siRNAs through fusion to an anti-gp120 aptamer. The envelope glycoprotein is expressed on the surface of HIV-1-infected cells, allowing binding and internalization of the aptamer–siRNA chimeric molecules.Author: Jiehua Zhou, Haitang Li, Shirley Li, John Zaia, John J Rossi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197064/
Based upon the best aptamer A-1, we also create a novel dual inhibitory function anti-gp120 aptamer-siRNA chimera in which both the aptamer and the siRNA portions have potent anti-HIV activities. Further, we utilize the gp120 aptamer-siRNA chimeras for cell-type specific delivery of the siRNA into HIV-1 …Author: Jiehua Zhou, Haitang Li, Jane Zhang, Swiderski Piotr, John Rossi
https://jim.bmj.com/content/62/7/914
Oct 01, 2014 · The combined use of small interfering RNA (siRNAs) and aptamers could effectively block viral replication and prevent the emergence of resistant variants. The present review offers a brief overview of the use of cell-type–specific aptamer and aptamer-siRNA conjugates’ development in our group for the treatment of HIV-1.Author: Jiehua Zhou, John Rossi
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