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https://www.sciencedirect.com/science/article/pii/S0304419X08000176
1. Cell-penetrating peptides (CPPs) The efficient passage of drugs through the plasma membrane remains a major hurdle for drug delivery. Good cell uptake often requires the administration of high quantities of drugs in order to obtain the expected intracellular biological effect.Author: Eric Vivès, Julien Schmidt, André Pèlegrin
https://link.springer.com/article/10.1023/B:PHAM.0000019289.61978.f5
Mar 01, 2004 · Protein transduction domains (PTDs) are small cationic peptides that can facilitate the uptake of large, biologically active molecules into mammalian cells. Recent reports have suggested that PTDs may be able to mediate the delivery of cargo to tissues throughout a living organism. Such technology could eliminate the size restrictions on usable drugs, enabling previously unavailable large ...Author: Eric L. Snyder, Steven F. Dowdy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482480/
Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. Biopolymers. 2008b; 90:604–10. Torchilin VP, Rammohan R, Weissig V, Levchenko TS. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors.Author: Erez Koren, Anjali Apte, Rupa R. Sawant, Jacob Grunwald, Vladimir P. Torchilin
https://pubs.acs.org/doi/10.1021/acs.langmuir.8b03175
In this work, we report a drug delivery system based on the pH-responsive self-assembly and -disassembly behaviors of peptides. Here, a systematically designed histidine-rich lipidated peptide (NP1) is presented to encapsulate and deliver an anticancer drug ellipticine (EPT) into two model cells: non-small-cell lung carcinoma and Chinese hamster ovary cells. The mechanism of pH-responsive ...Author: Lei Zhang, Jiang Xu, Feng Wang, Yong Ding, Toby Wang, Grace Jin, Matthew Martz, Zhongzheng Gui, Ping...
https://www.sciencedirect.com/topics/neuroscience/cell-penetrating-peptide
Yousef Javadzadeh, Leila Azharshekoufeh Bahari, in Nano- and Microscale Drug Delivery Systems, 2017. 3.5 Cell-Penetrating Peptides. Cell-penetrating peptides (CPPs) are short peptide sequences with positive charge and rich in lysine or arginine.
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