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https://clinicaltrials.gov/ct2/show/NCT03566199
Jun 25, 2018 · I. To determine the clinical efficacy of repeated administration of MTX110 given by intratumoral convection-enhanced delivery (CED) in children with newly diagnosed DIPG in the confines of a phase I and early efficacy study. OUTLINE: This is …
https://clinicaltrials.gov/ct2/show/NCT01502917
Jan 02, 2012 · The researchers will use "convection-enhanced delivery" (CED) to deliver an agent called 124I-8H9. CED is performed during surgery. The study agent is infused through a small tube placed into the tumor in the brain. Many studies have shown this can safely be done in animals but this study is the first time 124I-8H9 will be given by CED in humans.
https://braintumorcenter.ucsf.edu/treatment/experimental-diagnostics-therapies/convection-enhanced-delivery
Increasing dosages would not work either, since these medications would reach toxic concentrations in the body before reaching effective concentrations in the brain. To address this problem, researchers at UCSF and elsewhere have been developing a procedure called convection-enhanced delivery (CED). CED is an experimental technique for directly infusing drugs into a brain tumor.
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30322-X/fulltext
Convection-enhanced delivery in the brainstem of children with diffuse intrinsic pontine glioma who have previously received radiation therapy seems to be a rational and safe therapeutic strategy. PET-based dosimetry of the radiolabelled antibody [124I]-8H9 validated the principle of using convection-enhanced delivery in the brain to achieve high intra-lesional dosing with negligible systemic ...Author: Mark M Souweidane, Mark M Souweidane, Kim Kramer, Kim Kramer, Neeta Pandit-Taskar, Neeta Pandit-Task...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657605/
The brain is highly accessible for nutrients and oxygen, however delivery of drugs to malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment.Author: Waldemar Debinski, Stephen B Tatter
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